The expression of renal Epstein-Barr virus markers in patients with lupus nephritis

The aim of this study was to investigate the role of renal Epstein-Barr virus (EBV) infection in the pathogenesis of lupus nephritis (LN). A total of 58 renal tissue samples from patients with LN, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue sampl...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2014-05, Vol.7 (5), p.1135-1140
Main Authors: YU, XIAO-XIA, YAO, CUI-WEI, TAO, JING-LI, YANG, CHEN, LUO, MIAN-NA, LI, SHANG-MEI, LIU, HUA-FENG
Format: Article
Language:English
Subjects:
Analysis
Antigens
autoantibodies
Biopsy
Causes of
Diagnosis
Epstein-Barr virus
Health aspects
Humidity
Hybridization
Infections
Lupus
lupus nephritis
Nephritis
Pathogenesis
Physiological aspects
Proteins
renal tissues
Rodents
Substance abuse treatment
Viral infections
Viral proteins
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Summary:The aim of this study was to investigate the role of renal Epstein-Barr virus (EBV) infection in the pathogenesis of lupus nephritis (LN). A total of 58 renal tissue samples from patients with LN, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue samples from patients with minimal change nephropathy were collected. The expression of EBV-latent membrane protein-1 (EBV-LMP1) and EBV-encoded RNA 1 (EBER-1) in the renal tissue was examined by immunohistochemistry (IHC) and in situ hybridization (ISH), respectively. The sera levels of anti-nuclear antibody as well as antibodies to extractable nuclear antigen in patients with LN were also measured. An equivalence test showed that the results from the IHC and the ISH analyses had strong agreement. The positive rates of renal EBER-1 and EBV-LMP1 in the LN patients were significantly higher than those of the normal and minimal change nephropathy patients (P0.05). The positive rates of EBV-LMP1 and EBER-1 in the renal tissues of patients with LN were not determined to be significantly different between the relapse (immunosuppressant-treated) and initial onset (non-treated) patients, between the patients with and without concurrent infection, and among the patients with different age ranges (P>0.05). The proportion of LN patients positive for anti-Sm antibody was significantly higher in the renal EBV-positive group than in the EBV-negative group (P0.05). The present study shows that renal EBV infection may contribute to the pathogenesis of LN by inducing anti-Sm antibody production.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.1578