Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing

We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also...

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Bibliographic Details
Published in:Optics letters 2013-06, Vol.38 (12), p.2038-2040
Main Authors: Rice, William L, Hou, Steven, Kumar, Anand T N
Format: Article
Language:English
Subjects:
Asymptotic properties
Decay
Diffusion
Fluorescence
Image Enhancement - methods
Imaging, Three-Dimensional
Multiplexing
Optical Imaging - methods
Phantoms, Imaging
Point spread functions
Spectrometry, Fluorescence
Time domain
Tomography
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Summary:We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable to achieve this separation, indicating the unique advantage of a decay-amplitude-based approach for tomographic lifetime multiplexing with time domain data.
ISSN:0146-9592
1539-4794
DOI:10.1364/OL.38.002038