Comparative Microbiological Studies of Transcription Inhibitors Fidaxomicin and the Rifamycins in Clostridium difficile

Fidaxomicin (FDX) is a narrow-spectrum antibiotic for the treatment of Clostridium difficile-associated diarrhea. While FDX and rifamycins share the same target (RNA polymerase), FDX exhibits a unique mode of action distinct from that of rifamycins. In comparative microbiological studies with C. dif...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-05, Vol.58 (5), p.2934-2937
Main Authors: BABAKHANI, Farah, SEDDON, Jaime, SEARS, Pamela
Format: Article
Language:English
Subjects:
Aminoglycosides
Aminoglycosides - pharmacology
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clostridium
Clostridium difficile
Clostridium difficile - drug effects
Gastroenterology. Liver. Pancreas. Abdomen
Mechanisms of Action: Physiological Effects
Medical sciences
Microbial Sensitivity Tests
Other diseases. Semiology
Pharmacology. Drug treatments
Rifamycins
Rifamycins - pharmacology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Fidaxomicin (FDX) is a narrow-spectrum antibiotic for the treatment of Clostridium difficile-associated diarrhea. While FDX and rifamycins share the same target (RNA polymerase), FDX exhibits a unique mode of action distinct from that of rifamycins. In comparative microbiological studies with C. difficile, FDX interacted synergistically with rifamycins, demonstrated a lower propensity for the development of resistance to rifamycins, and exhibited no cross-resistance with rifamycins. These results highlight differences in the mechanisms of action of FDX and rifamycins.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.02572-13