CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect

Immunization with attenuated Plasmodium sporozoites or viral vectored vaccines can induce protective CD8(+) T cells that can find and eliminate liver-stage malaria parasites. A key question is whether CD8(+) T cells must recognize and eliminate each parasite in the liver or whether bystander killing...

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Bibliographic Details
Published in:Infection and immunity 2014-04, Vol.82 (4), p.1460-1464
Main Authors: Cockburn, Ian A, Tse, Sze-Wah, Zavala, Fidel
Format: Article
Language:English
Subjects:
Animals
Antigens, Protozoan - immunology
Bystander Effect - immunology
CD8-Positive T-Lymphocytes - physiology
Hepatocytes - parasitology
Host Response and Inflammation
Liver - parasitology
Malaria - immunology
Mice
Mice, Inbred C57BL
Parasite Load
Plasmodium berghei
Plasmodium berghei - immunology
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Summary:Immunization with attenuated Plasmodium sporozoites or viral vectored vaccines can induce protective CD8(+) T cells that can find and eliminate liver-stage malaria parasites. A key question is whether CD8(+) T cells must recognize and eliminate each parasite in the liver or whether bystander killing can occur. To test this, we transferred antigen-specific effector CD8(+) T cells to mice that were then coinfected with two Plasmodium berghei strains, only one of which could be recognized directly by the transferred T cells. We found that the noncognate parasites developed normally in these mice, demonstrating that bystander killing of parasites does not occur during the CD8(+) T cell response to malaria parasites. Rather, elimination of infected parasites is likely mediated by direct recognition of infected hepatocytes by antigen-specific CD8(+) T cells.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01500-13