Application of Genomic Principles to Pharmacotherapy of Cancer

Objectives. To teach first-year (P1) pharmacy students to apply the principles of pharmacogenomics underlying clinical pharmacotherapeutics to cancer patients. Design. Using polymerase chain reaction (PCR) and high-resolution melting analysis of deoxyribonucleic acid (DNA) from colorectal cancer cel...

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Bibliographic Details
Published in:American journal of pharmaceutical education 2014-04, Vol.78 (3), p.55-55, Article 55
Main Authors: Farrell, Christopher L., Pedigo, Nancy G., Messersmith, Amy R.
Format: Article
Language:English
Subjects:
Active Learning
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biochemistry
Cancer
Cancer therapies
Care and treatment
Cell Line, Tumor
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - genetics
Comprehension
Curriculum
DNA Mutational Analysis
Education, Pharmacy - methods
Educational Environment
Female
Fundamental Concepts
Genes
Genetic Predisposition to Disease
Genetics
genomics
Genomics - education
Humans
Instructional Design and Assessment
Kinases
Laboratories
Learning
Male
Medical Oncology - education
Medical research
Middle Aged
Mutation
Oncology
Patients
Pharmacogenetics
Pharmacogenetics - education
pharmacogenomics
pharmacotherapy
Pharmacy
Phenotype
Polymerase Chain Reaction
Precision Medicine
Proto-Oncogene Proteins B-raf - genetics
Radiology
Student Centered Learning
Study and teaching
Teaching - methods
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Summary:Objectives. To teach first-year (P1) pharmacy students to apply the principles of pharmacogenomics underlying clinical pharmacotherapeutics to cancer patients. Design. Using polymerase chain reaction (PCR) and high-resolution melting analysis of deoxyribonucleic acid (DNA) from colorectal cancer cell lines to determine the presence of somatic mutations for an oncogenic marker, students formulated the proper course of treatment for a patient with similar tumor genomics. Assessment. In a postintervention survey, students highly rated the effectiveness of the laboratory session for learning pharmacogenomics, and subsequent examination scores reflected retention of principles and understanding of clinical application. Conclusion. The pharmacogenomic laboratory exercise prepared students to understand how genetic markers give clinical insight into the appropriate application of drugs in oncology pharmacotherapy. Further, the session inspired their interest in learning more about pharmacogenomics and their professional roles in personalized medicine.
ISSN:0002-9459
1553-6467
DOI:10.5688/ajpe78355