Molecular structure, function, and dynamics of clathrin-mediated membrane traffic

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate i...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2014-05, Vol.6 (5), p.a016725-a016725
Main Authors: Kirchhausen, Tom, Owen, David, Harrison, Stephen C
Format: Article
Language:English
Subjects:
Actins - physiology
Animals
Auxilins - chemistry
Auxilins - physiology
Biological Transport
Cell Membrane - metabolism
Clathrin - chemistry
Clathrin - physiology
Coated Pits, Cell-Membrane - physiology
Dynamins - chemistry
Dynamins - physiology
Humans
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Summary:Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit, loading its contents, pinching off the membrane as a lattice-enclosed vesicle, and recycling the components. It integrates as much of the structural information as possible at the time of writing into a sketch of the principal steps in coated-pit and coated-vesicle formation.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a016725