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Breaking the LSD1/KDM1A Addiction: Therapeutic Targeting of the Epigenetic Modifier in AML

KDM1A/LSD1, a histone H3K4/K9 demethylase and epigenetic regulator with roles in both gene activation and repression, has increased expression in multiple cancer types. Harris et al., in this issue of Cancer Cell, and Schenk et al. show that KDM1A may be a viable therapeutic target in treating AML....

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Bibliographic Details
Published in:Cancer cell 2012-04, Vol.21 (4), p.451-453
Main Authors: Lokken, Alyson A., Zeleznik-Le, Nancy J.
Format: Article
Language:English
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Summary:KDM1A/LSD1, a histone H3K4/K9 demethylase and epigenetic regulator with roles in both gene activation and repression, has increased expression in multiple cancer types. Harris et al., in this issue of Cancer Cell, and Schenk et al. show that KDM1A may be a viable therapeutic target in treating AML.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2012.03.027