Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmenta...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-14
Main Authors: Acimovic, Ivana, Vilotic, Aleksandra, Pesl, Martin, Lacampagne, Alain, Dvorak, Petr, Rotrekl, Vladimir, Meli, Albano C.
Format: Article
Language:English
Subjects:
Cardiomyocytes
Efficiency
Embryonic stem cells
Gene expression
Genomes
Health aspects
Heart attacks
Heart cells
Heart failure
Humans
Mortality
Myocytes, Cardiac
Pluripotent Stem Cells
Review
Stem Cell Research
Stem cells
Transcription factors
Tumors
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Summary:Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/512831