fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies

Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and medias...

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Bibliographic Details
Published in:Current oncology (Toronto) 2014-04, Vol.21 (2), p.e345-348
Main Authors: de Blank, P, Cole, K, Kersun, L, Green, A, Wilkes, J J, Belasco, J, Bagatell, R, Bailey, L C, Fisher, M J
Format: Article
Language:English
Subjects:
Case Report
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Summary:Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although (18)F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.
ISSN:1198-0052
1718-7729
1718-7729
DOI:10.3747/co.21.1803