A novel mosquito-borne Orbivirus species found in South-east Asia

The genus Orbivirus of the family Reoviridae includes a genetically diverse group of dsRNA arthropod-borne viruses that infect a wide variety of animal species. Here, we report the complete genome and phylogenetic analysis of a novel orbivirus (IAn-66411 or Sathuvachari virus, SVIV) isolated in 1963...

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Bibliographic Details
Published in:Journal of general virology 2013-05, Vol.94 (Pt 5), p.1051-1057
Main Authors: Kapoor, Amit, Tesh, Robert B, Duraisamy, Raja, Popov, Vsevolod L, Travassos da Rosa, Amelia P A, Lipkin, W Ian
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animal
Animals
Base Sequence
Bird Diseases - transmission
Bird Diseases - virology
Cell Line
Chlorocebus aethiops
Cricetinae
Culicidae - virology
Genome, Viral - genetics
India
Insect Vectors - virology
Mice
Molecular Sequence Data
Orbivirus - classification
Orbivirus - genetics
Orbivirus - isolation & purification
Orbivirus - ultrastructure
Phylogeny
Reoviridae Infections - transmission
Reoviridae Infections - veterinary
Reoviridae Infections - virology
RNA, Viral - genetics
RNA-Dependent RNA Polymerase - genetics
Sequence Analysis, DNA
Short Communication
Starlings - virology
Vero Cells
Viral Core Proteins - genetics
Viral Nonstructural Proteins - genetics
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Summary:The genus Orbivirus of the family Reoviridae includes a genetically diverse group of dsRNA arthropod-borne viruses that infect a wide variety of animal species. Here, we report the complete genome and phylogenetic analysis of a novel orbivirus (IAn-66411 or Sathuvachari virus, SVIV) isolated in 1963 from starlings (Brahminy myna) collected in Vellore, Tamil Nadu, India. Comparative genetic analysis of the SVIV polymerase (VP1 protein), core protein (VP3) and outer core protein (VP7) confirmed that SVIV is most closely related to the mosquito-borne orbiviruses, but that it is equally divergent from all known species. Therefore, SVIV should be tentatively considered as the prototype of a novel mosquito-associated Orbivirus species. These findings will aid in the development of molecular reagents that can identify genetically similar orbiviruses and help elucidate their geographical distribution, epidemiology, species tropism and possible disease association.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.046748-0