The development and function of follicular helper T cells in immune responses

Follicular helper T cells （Tfh） have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particula...

Full description

Saved in:
Bibliographic Details
Published in:Cellular & molecular immunology 2012-09, Vol.9 (5), p.375-379
Main Authors: Chen, Maogen, Guo, Zhiyong, Ju, Weiqiang, Ryffel, Bernhard, He, Xiaoshun, Zheng, Song Guo
Format: Article
Language:English
Subjects:
Animals
Antibodies
Autoimmune diseases
Autoimmune Diseases - immunology
B-Lymphocytes - immunology
Bcl-6 protein
Biomedical and Life Sciences
Biomedicine
Cell Differentiation
Development
Germinal Center - immunology
Germinal centers
Humans
Immunology
Interleukin 21
Interleukins - metabolism
Lymphocytes B
Lymphocytes T
Medical Microbiology
Microbiology
Microenvironments
Review
Reviews
Rheumatoid arthritis
Systemic lupus erythematosus
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
Transcription
T细胞
Vaccine
免疫应答
发育
滤泡
程序启动
类风湿关节炎
系统性红斑狼疮
自身免疫性疾病
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Follicular helper T cells （Tfh） have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.
ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2012.18