Invasive micropapillary carcinoma:A distinct type of adenocarcinomas in the gastrointestinal tract

Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary glands.Recent literature data shows that this histological lesion has also been found in...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-04, Vol.20 (16), p.4597-4606
Main Authors: Guzińska-Ustymowicz, Katarzyna, Niewiarowska, Katarzyna, Pryczynicz, Anna
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - classification
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Biomarkers, Tumor - analysis
carcinoma
Carcinoma, Papillary - chemistry
Carcinoma, Papillary - classification
Carcinoma, Papillary - pathology
Carcinoma, Papillary - secondary
Cell Adhesion
Gastrointestinal Neoplasms - chemistry
Gastrointestinal Neoplasms - classification
Gastrointestinal Neoplasms - pathology
Humans
Immunohistochemistry
Invasive
Lymph
Lymphatic Metastasis
micropapillary
MUC-1
Neoplasm Grading
Neoplasm Invasiveness
node
Predictive Value of Tests
Review
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Summary:Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary glands.Recent literature data shows that this histological lesion has also been found in cancers of the gastrointestinal system.The micropapillary components are clusters of neoplastic cells that closely adhere to each other and are located in distinct empty spaces.Moreover,clusters of neoplastic cells do not have a fibrousvascular core.The IMPC cells show reverse polarity resulting in typical‘’inside-out’’structures that determines secretary properties,disturbs adhesion and conditions grade of malignancy in gastrointestinal(GI)tract.Invasive micropapillary carcinoma in this location is associated with metastases to local lymph nodes and lymphovascular invasion.IMPC can be a prognostic factor for patients with cancers of the stomach,pancreas and with colorectal cancer since it is related with diseasefree and overall survival.The purpose of this review is to present the characterization of invasive micropapillary carcinoma in colon,rectum,stomach and others site of GI tract,and to determine the immunohistological indentification of IMPC in those localization.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i16.4597