Oral lesions among HIV‐infected children on antiretroviral treatment in West Africa

• Published in: Tropical medicine & international health 2014-03, Vol.19 (3), p.246-255
• Main Authors: Meless, David, Ba, Boubacar, Faye, Malick, Diby, Jean‐Serge, N'zoré, Serge, Datté, Sébastien, Diecket, Lucrèce, N'Diaye, Clémentine, Aka, Edmond Addi, Kouakou, Kouadio, Ba, Abou, Ekouévi, Didier Koumavi, Dabis, François, Shiboski, Caroline, Arrivé, Elise
• Format: Article
• Language: English
• Subjects: Adolescent; Africa; Africa, Western - epidemiology; Anti-Retroviral Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral drugs; antiretroviral therapy; Antiviral agents; Biological and medical sciences; CD4 Lymphocyte Count; Child; Child, Preschool; Childrens health; Confidence Intervals; Cross-Sectional Studies; Côte d'Ivoire; Dental Caries - epidemiology; Dental health; Disease Progression; Female; General aspects; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - immunology; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Logistic Models; Male; Mali; Medical sciences; Mouth; Mouth Diseases - epidemiology; Mouth Diseases - pathology; Mouth Diseases - virology; Odds Ratio; oral health; Oral Health - statistics & numerical data; Oral Hygiene - statistics & numerical data; Parotid Gland - pathology; Pharmacology. Drug treatments; Sénégal; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 1360-2276; 1365-3156
• DOI: 10.1111/tmi.12253

Objective To estimate the prevalence of oral mucosal diseases and dental caries among HIV‐infected children receiving antiretroviral treatment (ART) in West Africa and to identify the factors associated with the prevalence of oral mucosal lesions. Methods Multicentre cross‐sectional survey in five paediatric HIV clinics in Côte d'Ivoire, Mali and Sénégal. A standardised examination was performed by trained dentists on a random sample of HIV‐infected children aged 5–15 years receiving ART. The prevalence of oral and dental lesions and mean number of decayed, missing/extracted and filled teeth (DMFdefT) in temporary and permanent dentition were estimated with their 95% confidence interval (95% CI). We used logistic regression to explore the association between children's characteristics and the prevalence of oral mucosal lesions, expressed as prevalence odds ratio (POR). Results The median age of the 420 children (47% females) enrolled was 10.4 years [interquartile range (IQR) = 8.3–12.6]. The median duration on ART was 4.6 years (IQR = 2.6–6.2); 84 (20.0%) had CD4 count