Uterine NK cells: active regulators at the maternal-fetal interface

Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist t...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 2014-05, Vol.124 (5), p.1872-1879
Main Authors: Moffett, Ashley, Colucci, Francesco
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Antigens
Biomedical research
Female
Fetuses
Genetic diversity
Humans
Immune system
Killer cells
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Ligands
Lymphocytes
Physiological aspects
Physiological research
Placenta - cytology
Placenta - immunology
Placentation - immunology
Pregnancy
Pregnancy - immunology
Review
Uterus - cytology
Uterus - immunology
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113
cites cdi_FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113
container_end_page 1879
container_issue 5
container_start_page 1872
container_title The Journal of clinical investigation
container_volume 124
creator Moffett, Ashley
Colucci, Francesco
description Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.
doi_str_mv 10.1172/JCI68107
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4001528</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A371285300</galeid><sourcerecordid>A371285300</sourcerecordid><originalsourceid>FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113</originalsourceid><addsrcrecordid>eNqN0ltrFDEUAOBBFLtWwV8gA4Low9RcJ0kfhLJ4WS0WtPoaMpkzsynZSZ1kiv57s7qtHdmHkoeQ5Msh5-QUxVOMjjAW5PXH5aqWGIl7xQJzLitJqLxfLBAiuFKCyoPiUYwXCGHGOHtYHBAmpJJCLYrltwSjG6D8_Km04H08Lo1N7grKEfrJmxTGWJpUpjWUG5PtYHzVQTK-dENedsbC4-JBZ3yEJ7v5sDh_9_Z8-aE6PXu_Wp6cVlYwkiqpkJWE2Jooyqi0Ne8MY1i1rKaWMFxz0TYIoCWMU8k7qkQjmlYx1TQtxvSwePM37OXUbKC1MKTReH05uo0Zf-lgnJ6fDG6t-3ClWU6cE5kDvNwFGMOPCWLSGxe3SZsBwhQ15owhLJhUd6AE05wHJZk-_49ehGlbpj-KK4HrGv9TvfGg3dCF_ES7DapPqMBEcopQVtUe1cMAOZ8wQOfy9swf7fF5tLBxdu-FV7ML2ST4mXozxahXX7_c3Z59n9sXt-wajE_rGPyUXBjiHO4Ka8cQ4wjdzf9hpLe9rK97OdNnt__7Bl43L_0NHYbneQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1525971661</pqid></control><display><type>article</type><title>Uterine NK cells: active regulators at the maternal-fetal interface</title><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Moffett, Ashley ; Colucci, Francesco</creator><creatorcontrib>Moffett, Ashley ; Colucci, Francesco</creatorcontrib><description>Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI68107</identifier><identifier>PMID: 24789879</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Anatomy &amp; physiology ; Animals ; Antigens ; Biomedical research ; Female ; Fetuses ; Genetic diversity ; Humans ; Immune system ; Killer cells ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Ligands ; Lymphocytes ; Physiological aspects ; Physiological research ; Placenta - cytology ; Placenta - immunology ; Placentation - immunology ; Pregnancy ; Pregnancy - immunology ; Review ; Uterus - cytology ; Uterus - immunology ; Veins &amp; arteries</subject><ispartof>The Journal of clinical investigation, 2014-05, Vol.124 (5), p.1872-1879</ispartof><rights>COPYRIGHT 2014 American Society for Clinical Investigation</rights><rights>Copyright American Society for Clinical Investigation May 2014</rights><rights>Copyright © 2014, American Society for Clinical Investigation 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113</citedby><cites>FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001528/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001528/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24789879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moffett, Ashley</creatorcontrib><creatorcontrib>Colucci, Francesco</creatorcontrib><title>Uterine NK cells: active regulators at the maternal-fetal interface</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.</description><subject>Anatomy &amp; physiology</subject><subject>Animals</subject><subject>Antigens</subject><subject>Biomedical research</subject><subject>Female</subject><subject>Fetuses</subject><subject>Genetic diversity</subject><subject>Humans</subject><subject>Immune system</subject><subject>Killer cells</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Physiological aspects</subject><subject>Physiological research</subject><subject>Placenta - cytology</subject><subject>Placenta - immunology</subject><subject>Placentation - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy - immunology</subject><subject>Review</subject><subject>Uterus - cytology</subject><subject>Uterus - immunology</subject><subject>Veins &amp; arteries</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqN0ltrFDEUAOBBFLtWwV8gA4Low9RcJ0kfhLJ4WS0WtPoaMpkzsynZSZ1kiv57s7qtHdmHkoeQ5Msh5-QUxVOMjjAW5PXH5aqWGIl7xQJzLitJqLxfLBAiuFKCyoPiUYwXCGHGOHtYHBAmpJJCLYrltwSjG6D8_Km04H08Lo1N7grKEfrJmxTGWJpUpjWUG5PtYHzVQTK-dENedsbC4-JBZ3yEJ7v5sDh_9_Z8-aE6PXu_Wp6cVlYwkiqpkJWE2Jooyqi0Ne8MY1i1rKaWMFxz0TYIoCWMU8k7qkQjmlYx1TQtxvSwePM37OXUbKC1MKTReH05uo0Zf-lgnJ6fDG6t-3ClWU6cE5kDvNwFGMOPCWLSGxe3SZsBwhQ15owhLJhUd6AE05wHJZk-_49ehGlbpj-KK4HrGv9TvfGg3dCF_ES7DapPqMBEcopQVtUe1cMAOZ8wQOfy9swf7fF5tLBxdu-FV7ML2ST4mXozxahXX7_c3Z59n9sXt-wajE_rGPyUXBjiHO4Ka8cQ4wjdzf9hpLe9rK97OdNnt__7Bl43L_0NHYbneQ</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Moffett, Ashley</creator><creator>Colucci, Francesco</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>Uterine NK cells: active regulators at the maternal-fetal interface</title><author>Moffett, Ashley ; Colucci, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anatomy &amp; physiology</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biomedical research</topic><topic>Female</topic><topic>Fetuses</topic><topic>Genetic diversity</topic><topic>Humans</topic><topic>Immune system</topic><topic>Killer cells</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Physiological aspects</topic><topic>Physiological research</topic><topic>Placenta - cytology</topic><topic>Placenta - immunology</topic><topic>Placentation - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy - immunology</topic><topic>Review</topic><topic>Uterus - cytology</topic><topic>Uterus - immunology</topic><topic>Veins &amp; arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moffett, Ashley</creatorcontrib><creatorcontrib>Colucci, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Science in Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moffett, Ashley</au><au>Colucci, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uterine NK cells: active regulators at the maternal-fetal interface</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>124</volume><issue>5</issue><spage>1872</spage><epage>1879</epage><pages>1872-1879</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><abstract>Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.</abstract><cop>United States</cop><pub>American Society for Clinical Investigation</pub><pmid>24789879</pmid><doi>10.1172/JCI68107</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0021-9738
ispartof The Journal of clinical investigation, 2014-05, Vol.124 (5), p.1872-1879
issn 0021-9738
1558-8238
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4001528
source PubMed Central; EZB Electronic Journals Library
subjects Anatomy & physiology
Animals
Antigens
Biomedical research
Female
Fetuses
Genetic diversity
Humans
Immune system
Killer cells
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Ligands
Lymphocytes
Physiological aspects
Physiological research
Placenta - cytology
Placenta - immunology
Placentation - immunology
Pregnancy
Pregnancy - immunology
Review
Uterus - cytology
Uterus - immunology
Veins & arteries
title Uterine NK cells: active regulators at the maternal-fetal interface
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A33%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uterine%20NK%20cells:%20active%20regulators%20at%20the%20maternal-fetal%20interface&rft.jtitle=The%20Journal%20of%20clinical%20investigation&rft.au=Moffett,%20Ashley&rft.date=2014-05-01&rft.volume=124&rft.issue=5&rft.spage=1872&rft.epage=1879&rft.pages=1872-1879&rft.issn=0021-9738&rft.eissn=1558-8238&rft_id=info:doi/10.1172/JCI68107&rft_dat=%3Cgale_pubme%3EA371285300%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c742t-890c822c6293438c65fa4419d463c241657db0eed245385f397b7bd949bbd113%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1525971661&rft_id=info:pmid/24789879&rft_galeid=A371285300&rfr_iscdi=true