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An approach to the etiology of metabolic syndrome
Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflammatory subst...
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| Published in: | Colombia médica (Cali, Colombia) Colombia), 2013-01, Vol.44 (1), p.57-63 |
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| Main Authors: | , , |
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| Language: | English |
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| container_end_page | 63 |
| container_issue | 1 |
| container_start_page | 57 |
| container_title | Colombia médica (Cali, Colombia) |
| container_volume | 44 |
| creator | Muñoz Contreras, Angélica Bedoya Berrío, Gabriel Velásquez R, Claudia Mc |
| description | Increased prevalence of obesity in the world, especially accumulation
of abnormal amounts of visceral fat predisposes to insulin resistance,
which is the central role of metabolic syndrome (MS). Obesity can
deregulate the intracellular signaling of insulin due to the production
of inflammatory substances, chemoattractant proteins, adipokines and
molecules that trigger hormonal mediator potentials for destabilization
of signal transduction, leading to metabolic disorders such as
hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS
and of the genetic mechanisms involved in its etiology derives from the
combination of variants on genes involved and environmental factors
that predispose it. The purpose of this paper is to review the effects
of obesity in molecular and biochemical responses that trigger insulin
resistance and its relation to some candidate genes and the ancestral
component of the population. |
| doi_str_mv | 10.25100/cm.v44i1.813 |
| format | article |
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of abnormal amounts of visceral fat predisposes to insulin resistance,
which is the central role of metabolic syndrome (MS). Obesity can
deregulate the intracellular signaling of insulin due to the production
of inflammatory substances, chemoattractant proteins, adipokines and
molecules that trigger hormonal mediator potentials for destabilization
of signal transduction, leading to metabolic disorders such as
hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS
and of the genetic mechanisms involved in its etiology derives from the
combination of variants on genes involved and environmental factors
that predispose it. The purpose of this paper is to review the effects
of obesity in molecular and biochemical responses that trigger insulin
resistance and its relation to some candidate genes and the ancestral
component of the population.</description><identifier>ISSN: 0120-8322</identifier><identifier>EISSN: 1657-9534</identifier><identifier>DOI: 10.25100/cm.v44i1.813</identifier><identifier>PMID: 24892324</identifier><language>eng</language><publisher>Universidad del Valle - Facultad de Salud</publisher><subject>Metabolic syndrome, obesity, insulin resistance, genetics, ancestry ; Review</subject><ispartof>Colombia médica (Cali, Colombia), 2013-01, Vol.44 (1), p.57-63</ispartof><rights>Copyright 2013 - Columbia Médica</rights><rights>Copyright: © 2013 Universidad del Valle. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3103-ae7f2d8a89062898ffaf30484bb4d5434ba7c23d94a05d27168bde1b446fb0173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002015/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002015/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids></links><search><creatorcontrib>Muñoz Contreras, Angélica</creatorcontrib><creatorcontrib>Bedoya Berrío, Gabriel</creatorcontrib><creatorcontrib>Velásquez R, Claudia Mc</creatorcontrib><title>An approach to the etiology of metabolic syndrome</title><title>Colombia médica (Cali, Colombia)</title><description>Increased prevalence of obesity in the world, especially accumulation
of abnormal amounts of visceral fat predisposes to insulin resistance,
which is the central role of metabolic syndrome (MS). Obesity can
deregulate the intracellular signaling of insulin due to the production
of inflammatory substances, chemoattractant proteins, adipokines and
molecules that trigger hormonal mediator potentials for destabilization
of signal transduction, leading to metabolic disorders such as
hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS
and of the genetic mechanisms involved in its etiology derives from the
combination of variants on genes involved and environmental factors
that predispose it. The purpose of this paper is to review the effects
of obesity in molecular and biochemical responses that trigger insulin
resistance and its relation to some candidate genes and the ancestral
component of the population.</description><subject>Metabolic syndrome, obesity, insulin resistance, genetics, ancestry</subject><subject>Review</subject><issn>0120-8322</issn><issn>1657-9534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpVkF9LwzAUxYMobk4ffe8XaL03Sdv0RRjDfzDwRZ9DkiZbpG1KWgf99pZNB8KFC_ec-4NzCLlHyGiOAA-mzQ6ce8wEsguyxCIv0ypn_JIsASmkglG6IDfD8AVAKy7gmiwoFxVllC8JrrtE9X0MyuyTMSTj3iZ29KEJuykJLmntqHRovEmGqatjaO0tuXKqGezd716Rz-enj81run1_edust6lmCCxVtnS0FkpUUFBRCeeUY8AF15rXOWdcq9JQVldcQV7TEguha4ua88JpwJKtyOOJ23_r1tbGdmNUjeyjb1WcZFBe_lc6v5e7cJB8zgmYz4D0BDAxDEO07vyLII_dSdPKY3dy7m72Zye_nuP7zp7tJnol_47RzIMMENkP_0pyPQ</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Muñoz Contreras, Angélica</creator><creator>Bedoya Berrío, Gabriel</creator><creator>Velásquez R, Claudia Mc</creator><general>Universidad del Valle - Facultad de Salud</general><general>Universidad del Valle</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>An approach to the etiology of metabolic syndrome</title><author>Muñoz Contreras, Angélica ; Bedoya Berrío, Gabriel ; Velásquez R, Claudia Mc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3103-ae7f2d8a89062898ffaf30484bb4d5434ba7c23d94a05d27168bde1b446fb0173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Metabolic syndrome, obesity, insulin resistance, genetics, ancestry</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muñoz Contreras, Angélica</creatorcontrib><creatorcontrib>Bedoya Berrío, Gabriel</creatorcontrib><creatorcontrib>Velásquez R, Claudia Mc</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Colombia médica (Cali, Colombia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muñoz Contreras, Angélica</au><au>Bedoya Berrío, Gabriel</au><au>Velásquez R, Claudia Mc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An approach to the etiology of metabolic syndrome</atitle><jtitle>Colombia médica (Cali, Colombia)</jtitle><date>2013-01-01</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>57</spage><epage>63</epage><pages>57-63</pages><issn>0120-8322</issn><eissn>1657-9534</eissn><abstract>Increased prevalence of obesity in the world, especially accumulation
of abnormal amounts of visceral fat predisposes to insulin resistance,
which is the central role of metabolic syndrome (MS). Obesity can
deregulate the intracellular signaling of insulin due to the production
of inflammatory substances, chemoattractant proteins, adipokines and
molecules that trigger hormonal mediator potentials for destabilization
of signal transduction, leading to metabolic disorders such as
hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS
and of the genetic mechanisms involved in its etiology derives from the
combination of variants on genes involved and environmental factors
that predispose it. The purpose of this paper is to review the effects
of obesity in molecular and biochemical responses that trigger insulin
resistance and its relation to some candidate genes and the ancestral
component of the population.</abstract><pub>Universidad del Valle - Facultad de Salud</pub><pmid>24892324</pmid><doi>10.25100/cm.v44i1.813</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0120-8322 |
| ispartof | Colombia médica (Cali, Colombia), 2013-01, Vol.44 (1), p.57-63 |
| issn | 0120-8322 1657-9534 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4002015 |
| source | PubMed Central |
| subjects | Metabolic syndrome, obesity, insulin resistance, genetics, ancestry Review |
| title | An approach to the etiology of metabolic syndrome |
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