Genetics of stroke

• Published in: Acta pharmacologica Sinica 2010-09, Vol.31 (9), p.1055-1064
• Main Authors: Guo, Jin-min, Liu, Ai-jun, Su, Ding-feng
• Format: Article
• Language: English
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain Ischemia - etiology; Brain Ischemia - genetics; Brain Ischemia - immunology; Brain Ischemia - metabolism; Disease Models, Animal; Genetics; Humans; Immunology; Internal Medicine; Intracranial Hemorrhages - etiology; Intracranial Hemorrhages - genetics; Intracranial Hemorrhages - metabolism; Medical Microbiology; Pharmacology/Toxicology; Review; Stroke - etiology; Stroke - genetics; Vaccine; 单基因疾病; 发达国家; 流行病学; 组成部分; 脂质代谢; 遗传因素; 遗传学
• ISSN: 1671-4083; 1745-7254
• DOI: 10.1038/aps.2010.141

Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.