Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice

Group A streptococcus （GAS）, an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicit...

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Bibliographic Details
Published in:Cellular & molecular immunology 2009-02, Vol.6 (1), p.73-77
Main Authors: Ma, Cuiqing, Li, Caihong, Wang, Xiurong, Zeng, Ruihong, Yin, Xiaolin, Feng, Huidong, Wei, Lin
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Bacterial - blood
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
A群链球菌
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - immunology
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Biomedical and Life Sciences
Biomedicine
Carrier Proteins - genetics
Carrier Proteins - immunology
Disease Models, Animal
Female
Immune response
Immunization
Immunogenicity
Immunoglobulin G
Immunoglobulin G - blood
Immunology
M protein
Medical Microbiology
Mice
Mice, Inbred BALB C
Microbiology
M蛋白
Streptococcal Infections - immunology
Streptococcal Infections - prevention & control
Streptococcal Vaccines - genetics
Streptococcal Vaccines - immunology
Streptococcus
Streptococcus infections
Streptococcus pyogenes - immunology
Vaccine
保护率
免疫力
分子免疫学
浅表性感染
特异性IgG
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Summary:Group A streptococcus （GAS）, an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA （an Fn-binding protein expressed on the surface of GAS） with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular ＆ Molecular Immunology.
ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2009.10