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Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice
Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicit...
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Published in: | Cellular & molecular immunology 2009-02, Vol.6 (1), p.73-77 |
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creator | Ma, Cuiqing Li, Caihong Wang, Xiurong Zeng, Ruihong Yin, Xiaolin Feng, Huidong Wei, Lin |
description | Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular & Molecular Immunology. |
doi_str_mv | 10.1038/cmi.2009.10 |
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This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular & Molecular Immunology.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2009.10</identifier><identifier>PMID: 19254483</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antibodies ; Antibodies, Bacterial - blood ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; A群链球菌 ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Outer Membrane Proteins - immunology ; Bacterial Proteins - genetics ; Bacterial Proteins - immunology ; Biomedical and Life Sciences ; Biomedicine ; Carrier Proteins - genetics ; Carrier Proteins - immunology ; Disease Models, Animal ; Female ; Immune response ; Immunization ; Immunogenicity ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunology ; M protein ; Medical Microbiology ; Mice ; Mice, Inbred BALB C ; Microbiology ; M蛋白 ; Streptococcal Infections - immunology ; Streptococcal Infections - prevention & control ; Streptococcal Vaccines - genetics ; Streptococcal Vaccines - immunology ; Streptococcus ; Streptococcus infections ; Streptococcus pyogenes - immunology ; Vaccine ; 保护率 ; 免疫力 ; 分子免疫学 ; 浅表性感染 ; 特异性IgG</subject><ispartof>Cellular & molecular immunology, 2009-02, Vol.6 (1), p.73-77</ispartof><rights>The Chinese Society of Immunology 2009</rights><rights>Copyright Nature Publishing Group Feb 2009</rights><rights>The Chinese Society of Immunology 2009.</rights><rights>Copyright © Wanfang Data Co. 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All Rights Reserved.</rights><rights>Copyright © 2009 The Chinese Society of Immunology 2009 The Chinese Society of Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-db32f3be8ef811a9aa97506020ebf4aa53843bfc308ceebd8ed3ab8920a56e063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87787X/87787X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002543/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002543/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19254483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Cuiqing</creatorcontrib><creatorcontrib>Li, Caihong</creatorcontrib><creatorcontrib>Wang, Xiurong</creatorcontrib><creatorcontrib>Zeng, Ruihong</creatorcontrib><creatorcontrib>Yin, Xiaolin</creatorcontrib><creatorcontrib>Feng, Huidong</creatorcontrib><creatorcontrib>Wei, Lin</creatorcontrib><title>Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cellular & Molecular Immunology</addtitle><description>Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular & Molecular Immunology.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - immunology</subject><subject>A群链球菌</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - immunology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunology</subject><subject>M protein</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>M蛋白</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcal Infections - prevention & control</subject><subject>Streptococcal Vaccines - genetics</subject><subject>Streptococcal Vaccines - immunology</subject><subject>Streptococcus</subject><subject>Streptococcus infections</subject><subject>Streptococcus pyogenes - immunology</subject><subject>Vaccine</subject><subject>保护率</subject><subject>免疫力</subject><subject>分子免疫学</subject><subject>浅表性感染</subject><subject>特异性IgG</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkt9v0zAQxyMEYqPwxDtYIPEAdPhXHOcFqaq2MWkTSINny3EvqUdid46z0f71uEtVBkIgP1i2P_7e3fcuy54TfEQwkx9MZ48oxmU6PcgOKeZ0iikVD7NDIgo6LYQkB9mTvr_COJe84I-zA1LSnHPJDrN4aTvb6oBmlW1tXCNfo5NKz9CtjUt0gb4EH8E6FD06bq2xcbwx0d4AOuu6wW0_zRptXR_RafDDCs3QZQywit54Y4YezZe6bcE1gJLQhTXwNHtU67aHZ7t9kn07Of46_zQ9_3x6Np-dT00uyzhdVIzWrAIJtSREl1qXRY4FphiqmmudM8lZVRuGpQGoFhIWTFeypFjnArBgk-zjqLsaqg4WBlwMulWrYDsd1sprq35_cXapGn-jOMbJIJYE3o4Ct9rV2jXqyg_BpZTVpunWPzYbBVvnMUkrwW920YK_HqCPqrO9gbbVDvzQKyHKQoqS_xekhBHMWZnA13-A-_i0EKn3lEr2L4oUMi84I6nVk-zdSJng-z5AvbeBYLWdI5XmSG2rUXe1vLjv3C92NzgJeD8CfXpKrQ33gv5V7-WIOx2HAHu9xGyRO-LVLr-ld8110lSVNt9r24KipcjT4Ar2E-4A6Ek</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Ma, Cuiqing</creator><creator>Li, Caihong</creator><creator>Wang, Xiurong</creator><creator>Zeng, Ruihong</creator><creator>Yin, Xiaolin</creator><creator>Feng, Huidong</creator><creator>Wei, Lin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice</title><author>Ma, Cuiqing ; Li, Caihong ; Wang, Xiurong ; Zeng, Ruihong ; Yin, Xiaolin ; Feng, Huidong ; Wei, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-db32f3be8ef811a9aa97506020ebf4aa53843bfc308ceebd8ed3ab8920a56e063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - 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subjects | Animals Antibodies Antibodies, Bacterial - blood Antigens, Bacterial - genetics Antigens, Bacterial - immunology A群链球菌 Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology Biomedical and Life Sciences Biomedicine Carrier Proteins - genetics Carrier Proteins - immunology Disease Models, Animal Female Immune response Immunization Immunogenicity Immunoglobulin G Immunoglobulin G - blood Immunology M protein Medical Microbiology Mice Mice, Inbred BALB C Microbiology M蛋白 Streptococcal Infections - immunology Streptococcal Infections - prevention & control Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus Streptococcus infections Streptococcus pyogenes - immunology Vaccine 保护率 免疫力 分子免疫学 浅表性感染 特异性IgG |
title | Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice |
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