Baicalin attenuates oxygen-glucose deprivation- induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells

Aim： To determine whether the flavonoid baicalin attenuates oxygen-glucose deprivation （OGD）-induced injury by inhibiting oxidative stress-mediated 5-1ipoxygenase （5-LOX） activation in PC12 cells. Methods： The effects of baicalin and the 5-LOX inhibitor zileuton on the changes induced by OGD/recover...

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Published in:Acta pharmacologica Sinica 2010-02, Vol.31 (2), p.137-144
Main Authors: Li, Cheng-tan, Zhang, Wei-ping, Fang, San-hua, Lu, Yun-bi, Zhang, Li-hui, Qi, Ling-ling, Huang, Xue-qin, Huang, Xiao-jia, Wei, Er-qing
Format: Article
Language:English
Subjects:
Animals
Arachidonate 5-Lipoxygenase - metabolism
Biomedical and Life Sciences
Biomedicine
Enzyme Activation
Flavonoids - pharmacology
Glucose - metabolism
Hydrogen Peroxide - metabolism
Immunology
Internal Medicine
Medical Microbiology
Original
original-article
Oxidative Stress
Oxygen - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
PC12 Cells
PC12细胞
Pharmacology/Toxicology
Phosphorylation
Rats
Reactive Oxygen Species - metabolism
Vaccine
氧化应激
细胞损伤
葡萄糖
酶激活
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cited_by cdi_FETCH-LOGICAL-c541t-7360a8e85d2173c50693d6e96ceda74fde96e668184f116778368f53ebca8c723
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container_title Acta pharmacologica Sinica
container_volume 31
creator Li, Cheng-tan
Zhang, Wei-ping
Fang, San-hua
Lu, Yun-bi
Zhang, Li-hui
Qi, Ling-ling
Huang, Xue-qin
Huang, Xiao-jia
Wei, Er-qing
description Aim： To determine whether the flavonoid baicalin attenuates oxygen-glucose deprivation （OGD）-induced injury by inhibiting oxidative stress-mediated 5-1ipoxygenase （5-LOX） activation in PC12 cells. Methods： The effects of baicalin and the 5-LOX inhibitor zileuton on the changes induced by OGD/recovery or H2O2 （an exogenous reactive oxygen species [ROS]） in green fluorescent protein-5-LOX-transfected PC12 cells were compared. Results： Both baicalin and zileuton attenuated OGD/recovery- and H2O2-induced injury and inhibited OGD/recovery-induced production of 5-LOX metabolites （cysteinyl leukotrienes） in a concentration-dependent manner. However, baicalin did not reduce baseline cysteinyl leukotriene levels. Baicalin also reduced OGD/recovery-induced ROS production and inhibited 5-LOX translocation to the nuclear enve- lope and p38 phosphorylation induced by OGD/recovery and H2O2. In contrast, zileuton did not show these effects. Conclusion： Baicalin can inhibit 5-LOX activation after ischemic injury, which may partly result from inhibition of the ROS/p38 mitogenactivated protein kinase pathway.
doi_str_mv 10.1038/aps.2009.196
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Methods： The effects of baicalin and the 5-LOX inhibitor zileuton on the changes induced by OGD/recovery or H2O2 （an exogenous reactive oxygen species [ROS]） in green fluorescent protein-5-LOX-transfected PC12 cells were compared. Results： Both baicalin and zileuton attenuated OGD/recovery- and H2O2-induced injury and inhibited OGD/recovery-induced production of 5-LOX metabolites （cysteinyl leukotrienes） in a concentration-dependent manner. However, baicalin did not reduce baseline cysteinyl leukotriene levels. Baicalin also reduced OGD/recovery-induced ROS production and inhibited 5-LOX translocation to the nuclear enve- lope and p38 phosphorylation induced by OGD/recovery and H2O2. In contrast, zileuton did not show these effects. Conclusion： Baicalin can inhibit 5-LOX activation after ischemic injury, which may partly result from inhibition of the ROS/p38 mitogenactivated protein kinase pathway.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2009.196</identifier><identifier>PMID: 20139896</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Arachidonate 5-Lipoxygenase - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Enzyme Activation ; Flavonoids - pharmacology ; Glucose - metabolism ; Hydrogen Peroxide - metabolism ; Immunology ; Internal Medicine ; Medical Microbiology ; Original ; original-article ; Oxidative Stress ; Oxygen - metabolism ; p38 Mitogen-Activated Protein Kinases - metabolism ; PC12 Cells ; PC12细胞 ; Pharmacology/Toxicology ; Phosphorylation ; Rats ; Reactive Oxygen Species - metabolism ; Vaccine ; 氧化应激 ; 细胞损伤 ; 葡萄糖 ; 酶激活</subject><ispartof>Acta pharmacologica Sinica, 2010-02, Vol.31 (2), p.137-144</ispartof><rights>CPS and SIMM 2010</rights><rights>Copyright Nature Publishing Group Feb 2010</rights><rights>Copyright © 2010 CPS and SIMM 2010 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-7360a8e85d2173c50693d6e96ceda74fde96e668184f116778368f53ebca8c723</citedby><cites>FETCH-LOGICAL-c541t-7360a8e85d2173c50693d6e96ceda74fde96e668184f116778368f53ebca8c723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002841/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002841/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20139896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Cheng-tan</creatorcontrib><creatorcontrib>Zhang, Wei-ping</creatorcontrib><creatorcontrib>Fang, San-hua</creatorcontrib><creatorcontrib>Lu, Yun-bi</creatorcontrib><creatorcontrib>Zhang, Li-hui</creatorcontrib><creatorcontrib>Qi, Ling-ling</creatorcontrib><creatorcontrib>Huang, Xue-qin</creatorcontrib><creatorcontrib>Huang, Xiao-jia</creatorcontrib><creatorcontrib>Wei, Er-qing</creatorcontrib><title>Baicalin attenuates oxygen-glucose deprivation- induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>Aim： To determine whether the flavonoid baicalin attenuates oxygen-glucose deprivation （OGD）-induced injury by inhibiting oxidative stress-mediated 5-1ipoxygenase （5-LOX） activation in PC12 cells. Methods： The effects of baicalin and the 5-LOX inhibitor zileuton on the changes induced by OGD/recovery or H2O2 （an exogenous reactive oxygen species [ROS]） in green fluorescent protein-5-LOX-transfected PC12 cells were compared. Results： Both baicalin and zileuton attenuated OGD/recovery- and H2O2-induced injury and inhibited OGD/recovery-induced production of 5-LOX metabolites （cysteinyl leukotrienes） in a concentration-dependent manner. However, baicalin did not reduce baseline cysteinyl leukotriene levels. Baicalin also reduced OGD/recovery-induced ROS production and inhibited 5-LOX translocation to the nuclear enve- lope and p38 phosphorylation induced by OGD/recovery and H2O2. In contrast, zileuton did not show these effects. 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Methods： The effects of baicalin and the 5-LOX inhibitor zileuton on the changes induced by OGD/recovery or H2O2 （an exogenous reactive oxygen species [ROS]） in green fluorescent protein-5-LOX-transfected PC12 cells were compared. Results： Both baicalin and zileuton attenuated OGD/recovery- and H2O2-induced injury and inhibited OGD/recovery-induced production of 5-LOX metabolites （cysteinyl leukotrienes） in a concentration-dependent manner. However, baicalin did not reduce baseline cysteinyl leukotriene levels. Baicalin also reduced OGD/recovery-induced ROS production and inhibited 5-LOX translocation to the nuclear enve- lope and p38 phosphorylation induced by OGD/recovery and H2O2. In contrast, zileuton did not show these effects. Conclusion： Baicalin can inhibit 5-LOX activation after ischemic injury, which may partly result from inhibition of the ROS/p38 mitogenactivated protein kinase pathway.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20139896</pmid><doi>10.1038/aps.2009.196</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Animals
Arachidonate 5-Lipoxygenase - metabolism
Biomedical and Life Sciences
Biomedicine
Enzyme Activation
Flavonoids - pharmacology
Glucose - metabolism
Hydrogen Peroxide - metabolism
Immunology
Internal Medicine
Medical Microbiology
Original
original-article
Oxidative Stress
Oxygen - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
PC12 Cells
PC12细胞
Pharmacology/Toxicology
Phosphorylation
Rats
Reactive Oxygen Species - metabolism
Vaccine
氧化应激
细胞损伤
葡萄糖
酶激活
title Baicalin attenuates oxygen-glucose deprivation- induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells
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