The protective roles of autophagy in ischemic preconditioning

a process for the degradation of protein aggregates and dysfunctional organelles, is required for cellular homeostasis and cell survival in response to stress and is implicated in endogenous protection. Ischemic preconditioning is a brief and nonlethal episode of ischemia, confers protection against...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2013-05, Vol.34 (5), p.636-643
Main Authors: Yan, Wen-jun, Dong, Hai-long, Xiong, Li-ze
Format: Article
Language:English
Subjects:
Animals
Autophagy
Biomedical and Life Sciences
Biomedicine
Cell Survival
Humans
Immunology
Internal Medicine
Ischemic Preconditioning - methods
Medical Microbiology
Pharmacology/Toxicology
Review
Signal Transduction
Vaccine
保护作用
应激反应
细胞器
细胞存活
缺血再灌注
缺血预处理
自噬
非致命性
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Description
Summary:a process for the degradation of protein aggregates and dysfunctional organelles, is required for cellular homeostasis and cell survival in response to stress and is implicated in endogenous protection. Ischemic preconditioning is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion through the up-regulation of endogenous protec- tive mechanisms. Emerging evidence shows that autophagy is associated with the protective effect of ischemic preconditioning. This review summarizes recent progress in research on the functions and regulations of the autophagy pathway in preconditioning-induced protection and cellular survival.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2013.18