Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: The effect of clonal complex

Summary Background Staphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing. Methods 1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were...

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Bibliographic Details
Published in:The Journal of infection 2014-05, Vol.68 (5), p.426-439
Main Authors: Miller, Ruth R, Walker, A. Sarah, Godwin, Heather, Fung, Rowena, Votintseva, Antonina, Bowden, Rory, Mant, David, Peto, Timothy E.A, Crook, Derrick W, Knox, Kyle
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial diseases
Biological and medical sciences
Carriage duration
Carrier State - epidemiology
Carrier State - microbiology
Colonisation
General aspects
Genotype
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Middle Aged
Molecular Epidemiology
Molecular Typing
Nasal Mucosa - microbiology
spa-typing
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcal Protein A - genetics
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
United Kingdom - epidemiology
Young Adult
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Summary:Summary Background Staphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing. Methods 1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were re-swabbed after one month then every two months for median two years. All S. aureus isolates were spa -typed. Risk factors were collected from interviews and medical records. Results 32% carried S. aureus at recruitment (
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.12.013