A Review on Protocatechuic Acid and Its Pharmacological Potential

Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. Protocatechuic acid (PCA) is a type of widely distributed naturally occ...

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Bibliographic Details
Published in:ISRN pharmacology 2014, Vol.2014, p.952943-9
Main Authors: Kakkar, Sahil, Bais, Souravh
Format: Article
Language:English
Subjects:
Acids
Antioxidants
Cancer
Drug dosages
Fruits
Herbal medicine
Mortality
Oxidative stress
Polyphenols
Reproductive system
Review
Sperm
Toxicity
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Summary:Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid. PCA has structural similarity with gallic acid, caffeic acid, vanillic acid, and syringic acid which are well-known antioxidant compounds. More than 500 plants contain PCA as active constituents imparting various pharmacological activity and these effects are due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on polyphenols and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the pharmacological effects of PCA molecules in humans and the structural aspects that contribute to these effects.
ISSN:2090-5165
2090-5173
2090-5173
DOI:10.1155/2014/952943