Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsis

We investigated the diagnostic and prognostic utilities of procalcitonin (PCT), B-type natriuretic peptide (BNP), and neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with suspected sepsis, for whom sepsis was diagnosed clinically or based on PCT concentrations. PCT, BNP,...

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Bibliographic Details
Published in:BMC infectious diseases 2014-04, Vol.14 (1), p.224-224, Article 224
Main Authors: Hur, Mina, Kim, Hanah, Lee, Seungho, Cristofano, Flavia, Magrini, Laura, Marino, Rossella, Gori, Chiara Serena, Bongiovanni, Cristina, Zancla, Benedetta, Cardelli, Patrizia, Di Somma, Salvatore
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis
Biomarkers
Biomarkers - blood
Calcitonin - blood
Calcitonin Gene-Related Peptide
Child
Child, Preschool
Confidence intervals
Critical Illness
Emergency medical care
Family medical history
Female
Health aspects
Heart failure
Hospitals
Humans
Infant
Infant, Newborn
Infections
Intensive care
Lipocalins - blood
Male
Medical research
Medicine
Medicine, Experimental
Middle Aged
Mortality
Natriuretic Peptide, Brain - blood
Peptides
Predictive Value of Tests
Prognosis
Protein Precursors - blood
Sepsis
Sepsis - blood
Sepsis - diagnosis
Statistical analysis
Studies
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Summary:We investigated the diagnostic and prognostic utilities of procalcitonin (PCT), B-type natriuretic peptide (BNP), and neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with suspected sepsis, for whom sepsis was diagnosed clinically or based on PCT concentrations. PCT, BNP, and NGAL concentrations were measured in 340 patients and were followed up in 109 patients. All studied biomarkers were analyzed according to the diagnosis, severity, and clinical outcomes of sepsis. Clinical sepsis and PCT-based sepsis showed poor agreement (kappa = 0.2475). BNP and NGAL showed significant differences between the two groups of PCT-based sepsis (P = 0.0001 and P 
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-14-224