N-acetylcysteine infusion reduces the resistance index of renal artery in the early stage of systemic sclerosis

Aim： To evaluate resistance index （RI） changes in renal artery after N-acetylcysteine infusion in patients with systemic sclerosis. Methods： In an open-label study 40 patients with systemic sclerosis （SSc） were treated with N-acetylcysteine （NAC） iv infusion over 5 consecutive hours, at a dose of 0....

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Published in:Acta pharmacologica Sinica 2009-09, Vol.30 (9), p.1283-1288
Main Authors: Rosato, Edoardo, Cianci, Rosario, Barbano, Biagio, Menghi, Ginevra, Gigante, Antonietta, Rossi, Carmelina, Zardi, Enrico M, Amoroso, Antonio, Pisarri, Simonetta, Salsano, Felice
Format: Article
Language:English
Subjects:
Acetylcysteine - therapeutic use
Biomedical and Life Sciences
Biomedicine
Female
Free Radical Scavengers - therapeutic use
Humans
Immunology
Internal Medicine
Male
Medical Microbiology
Microscopic Angioscopy
Middle Aged
Original
original-article
Pharmacology/Toxicology
Renal Artery - drug effects
Renal Artery - physiology
Renal Artery Obstruction - drug therapy
Renal Artery Obstruction - physiopathology
Scleroderma, Systemic - complications
Scleroderma, Systemic - physiopathology
Vaccine
Vascular Resistance - drug effects
半胱氨酸
早期阶段
系统性
肾动脉
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Summary:Aim： To evaluate resistance index （RI） changes in renal artery after N-acetylcysteine infusion in patients with systemic sclerosis. Methods： In an open-label study 40 patients with systemic sclerosis （SSc） were treated with N-acetylcysteine （NAC） iv infusion over 5 consecutive hours, at a dose of 0.015 g.kg^-1.h^-1. Renal haemodynamic effects were evaluated by color Doppler examination before and after NAC infusion. Results： NAC infusion significantly reduced RI in a group of sclerodermic patients with early/active capillaroscopic pattern, modified Rodnan Total Skin Score （mRTSS） 〈14 and mild-moderate score to the vascular domain of Medsger Scleroderma Disease Severity Scale （DSS）. RI increased after NAC infusion in patients with late capillaroscopic pattern, mTRSS〉14 and severe-end stage score to the vascular domain of DSS. In patients with reduction of RI after NAC infusion, diffusion capacity for carbon monoxide mean value was significantly higher than in those patients with an increase of RI. No significant differences in renal blood flow were found between patients with different subsets of SSc. Conclusion： In patients with low disease severity NAC ameliorates vascular renal function.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2009.128