Emerging roles for platelets as immune and inflammatory cells

Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also immune cells that initiate and accelerate many vascular inflammatory conditions. Platelets are linked to the pathogenesi...

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Bibliographic Details
Published in:Blood 2014-05, Vol.123 (18), p.2759-2767
Main Authors: Morrell, Craig N., Aggrey, Angela A., Chapman, Lesley M., Modjeski, Kristina L.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Blood Platelets - immunology
Blood Platelets - metabolism
Cell Communication
Communicable Diseases - immunology
Communicable Diseases - metabolism
Endothelial Cells - metabolism
Humans
Immunity, Innate
Inflammation - immunology
Inflammation - metabolism
Review
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Summary:Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also immune cells that initiate and accelerate many vascular inflammatory conditions. Platelets are linked to the pathogenesis of inflammatory diseases such as atherosclerosis, malaria infection, transplant rejection, and rheumatoid arthritis. In some contexts, platelet immune functions are protective, whereas in others platelets contribute to adverse inflammatory outcomes. In this review, we will discuss platelet and platelet-derived mediator interactions with the innate and acquired arms of the immune system and platelet-vessel wall interactions that drive inflammatory disease. There have been many recent publications indicating both important protective and adverse roles for platelets in infectious disease. Because of this new accumulating data, and the fact that infectious disease continues to be a leading cause of death globally, we will also focus on new and emerging concepts related to platelet immune and inflammatory functions in the context of infectious disease.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2013-11-462432