Outcome for Adolescent and Young Adult Patients With Osteosarcoma: A Report From the Children's Oncology Group

There are conflicting data regarding age as a prognostic factor in osteosarcoma. The authors conducted a study evaluating the impact of age on prognosis in children and young adults with osteosarcoma enrolled on North American cooperative group trials. Patients with high-grade osteosarcoma of any si...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 2012-09, Vol.118 (18), p.4597-4605
Main Authors: JANEWAY, Katherine A, BARKAUSKAS, Donald A, KRAILO, Mark D, MEYERS, Paul A, SCHWARTZ, Cindy L, EBB, David H, SEIBEL, Nita L, GRIER, Holcombe E, GORLICK, Richard, MARINA, Neyssa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Biological and medical sciences
Bone Neoplasms - drug therapy
Child
Child, Preschool
Disease-Free Survival
Diseases of the osteoarticular system
Female
Humans
Infant
Male
Medical sciences
Neoplasm Recurrence, Local
Osteosarcoma - drug therapy
Prognosis
Treatment Outcome
Tumors
Tumors of striated muscle and skeleton
Young Adult
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There are conflicting data regarding age as a prognostic factor in osteosarcoma. The authors conducted a study evaluating the impact of age on prognosis in children and young adults with osteosarcoma enrolled on North American cooperative group trials. Patients with high-grade osteosarcoma of any site enrolled on North American cooperative group trials CCG-7943, POG-9754, INT-0133, and AOST0121 were included in this study. Primary tumor site, age, sex, ethnicity, histologic response, and presence of metastatic disease at diagnosis were evaluated for their impact on overall survival (OS) and event-free survival (EFS). A total of 1054 patients were eligible and had complete data available for the study. Age was not significantly associated with any other presenting covariate analyzed except sex. Age 18 or older was associated with a statistically significant poorer EFS (P = .019) and OS (P = .043). The 10-year EFS and OS in patients
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.27414