Lateralization of Motor Cortex Excitability in Stroke Patients during Action Observation : A TMS Study

Action observation activates the same motor areas as those involved in the performance of the observed actions and promotes functional recovery following stroke. Movement observation is now considered a promising tool for motor rehabilitation, by allowing patients to train their motor functions when...

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Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Fedeli, Marta, Marangon, Mattia, Piccione, Francesco, Tonin, Paolo, Masiero, Stefano, Priftis, Konstantinos
Format: Article
Language:English
Subjects:
Aged
Evoked Potentials, Motor - physiology
Female
Hand - physiology
Hand Strength - physiology
Humans
Male
Middle Aged
Motor ability
Motor Cortex - physiology
Muscle, Skeletal - physiology
Psychomotor Performance - physiology
Rehabilitation
Stroke
Stroke - physiopathology
Studies
Transcranial Magnetic Stimulation
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cited_by cdi_FETCH-LOGICAL-c565t-67acdb5c972df9b9ba93cbacb1a8be8aa7814b159df10c2cf1175ee2eb1c30f43
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creator Fedeli, Marta
Marangon, Mattia
Piccione, Francesco
Tonin, Paolo
Masiero, Stefano
Priftis, Konstantinos
description Action observation activates the same motor areas as those involved in the performance of the observed actions and promotes functional recovery following stroke. Movement observation is now considered a promising tool for motor rehabilitation, by allowing patients to train their motor functions when voluntary movement is partially impaired. We asked chronic-stroke patients, affected by either left (LHD) or right hemisphere (RHD) lesions, to observe either a left or right hand, while grasping a small target (eliciting a precision grip) or a large target (eliciting a whole hand grasp directed towards a target object). To better understand the effects of action observation on damaged motor circuits, we used transcranial magnetic stimulation (TMS) to induce motor evoked potentials (MEP) from two muscles of the unaffected hand in 10 completely hemiplegic participants. Results revealed that LHD patients showed MEP facilitation on the right (contralesional) M1 during action observation of hand-object interactions. In contrast, results showed no facilitation of the left (contralesional) M1 in RHD patients. Our results confirm that action observation might have a positive influence on the recovery of motor functions after stroke. Activating the motor system by means of action observation might provide a mechanism for improving function, at least in LHD patients.
doi_str_mv 10.1155/2014/251041
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subjects Aged
Evoked Potentials, Motor - physiology
Female
Hand - physiology
Hand Strength - physiology
Humans
Male
Middle Aged
Motor ability
Motor Cortex - physiology
Muscle, Skeletal - physiology
Psychomotor Performance - physiology
Rehabilitation
Stroke
Stroke - physiopathology
Studies
Transcranial Magnetic Stimulation
title Lateralization of Motor Cortex Excitability in Stroke Patients during Action Observation : A TMS Study
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