Bone Marrow Vascular Niche: Home for Hematopoietic Stem Cells

Though discovered later than osteoblastic niche, vascular niche has been regarded as an alternative indispensable niche operating regulation on hematopoietic stem cells (HSCs). As significant progresses gained on this type niche, it is gradually clear that the main work of vascular niche is undertak...

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Bibliographic Details
Published in:Bone Marrow Research 2014-01, Vol.2014 (2014), p.a1-8
Main Authors: Zhang, Lu, Li, Zongjin, He, Ningning, Cui, Jian
Format: Article
Language:English
Subjects:
Blood-vessels
Bone marrow
Hematopoiesis
Hematopoietic stem cells
Review
Stem cells
الأوعية الدموية
البحث العلمي
الخلايا الجذعية
نخاع العظم
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Summary:Though discovered later than osteoblastic niche, vascular niche has been regarded as an alternative indispensable niche operating regulation on hematopoietic stem cells (HSCs). As significant progresses gained on this type niche, it is gradually clear that the main work of vascular niche is undertaking to support hematopoiesis. However, compared to what have been defined in the mechanisms through which the osteoblastic niche regulates hematopoiesis, we know less in vascular niche. In this review, based on research data hitherto we will focus on component foundation and various functions of vascular niche that guarantee the normal hematopoiesis process within bone marrow microenvironments. And the possible pathways raised by various research results through which this environment undergoes its function will be discussed as well.
ISSN:2090-2999
2090-3006
DOI:10.1155/2014/128436