Nonprofessional Phagocytic Cell Receptors Involved in Staphylococcus aureus Internalization

Staphylococcus aureus is a successful human and animal pathogen. The majority of infections caused by this pathogen are life threatening, primarily because S. aureus has developed multiple evasion strategies, possesses intracellular persistence for long periods, and targets the skin and soft tissues...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Alva-Murillo, Nayeli, López-Meza, Joel Edmundo, Ochoa-Zarzosa, Alejandra
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bacteria
Bacterial Adhesion
Bacteriology
Cancer
Enzymes
Humans
Ligands
Metabolic disorders
Nosocomial infections
Pathogenesis
Phagocytosis
Protein Binding
Proteins
Receptors, Cell Surface - metabolism
Review
Staphylococcus aureus
Staphylococcus aureus - pathogenicity
Staphylococcus aureus - physiology
Staphylococcus infections
Virulence Factors - metabolism
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Summary:Staphylococcus aureus is a successful human and animal pathogen. The majority of infections caused by this pathogen are life threatening, primarily because S. aureus has developed multiple evasion strategies, possesses intracellular persistence for long periods, and targets the skin and soft tissues. Therefore, it is very important to understand the mechanisms employed by S. aureus to colonize and proliferate in these cells. The aim of this review is to describe the recent discoveries concerning the host receptors of nonprofessional phagocytes involved in S. aureus internalization. Most of the knowledge related to the interaction of S. aureus with its host cells has been described in professional phagocytic cells such as macrophages. Here, we showed that in nonprofessional phagocytes the α5β1 integrin host receptor, chaperons, and the scavenger receptor CD36 are the main receptors employed during S. aureus internalization. The characterization and identification of new bacterial effectors and the host cell receptors involved will undoubtedly lead to new discoveries with beneficial purposes.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/538546