Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients

• Published in: Journal of diabetes and its complications 2014-05, Vol.28 (3), p.353-359
• Main Authors: Jenkins, Alicia J, Fu, Dongxu, Azar, Madona, Stoner, Julie A, Kaufman, Derrick G, Zhang, Sarah, Klein, Richard L, Lopes-Virella, Maria F, Ma, Jian-xing, Lyons, Timothy J
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - blood; Blood pressure; Body mass index; Cardio-vascular risk factors; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cell culture; Colleges & universities; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Angiopathies - epidemiology; Diabetic retinopathy; Dyslipidemias - blood; Dyslipidemias - epidemiology; Endocrinology & Metabolism; Eye Proteins - blood; Glomerular Filtration Rate - physiology; Hispanic people; Humans; Incidence; Kidney - physiopathology; Lipids; Longitudinal Studies; Male; Middle Aged; Nerve Growth Factors - blood; PEDF; Predictive Value of Tests; Risk Factors; Rodents; Serpins - blood; Type 2 diabetes
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2014.01.008

Abstract Aim To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function. Methods PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n = 246) in whom serum was obtained early in the VADT (2.0 ± 0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years. Results Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p < 0.05). Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p > 0.09). Conclusions Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1 years.