Dynamics of urinary polyomavirus shedding in healthy adult women

The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary...

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Bibliographic Details
Published in:Journal of medical virology 2012-09, Vol.84 (9), p.1459-1463
Main Authors: Kling, Courtney L., Wright, Alexandra T., Katz, Sophie E., McClure, Gloria B., Gardner, J. Suzette, Williams, Jason T., Meinerz, Natalie M., Garcea, Robert L., Vanchiere, John A.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Asymptomatic Infections
Biological and medical sciences
BK virus
BK Virus - immunology
BK Virus - physiology
Epidemiology
Estrogens
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infectious diseases
JC virus
JC Virus - immunology
JC Virus - physiology
Medical sciences
Menstrual Cycle
Menstruation
Microbiology
Miscellaneous
polyomavirus
Polyomavirus Infections - blood
Polyomavirus Infections - urine
Polyomavirus Infections - virology
Tumor Virus Infections - blood
Tumor Virus Infections - urine
Tumor Virus Infections - virology
Viral diseases
Viral Load - physiology
Virology
Virus Replication
Virus Shedding
Young Adult
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Summary:The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.23319