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Dynamics of urinary polyomavirus shedding in healthy adult women
The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary...
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| Published in: | Journal of medical virology 2012-09, Vol.84 (9), p.1459-1463 |
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| container_end_page | 1463 |
| container_issue | 9 |
| container_start_page | 1459 |
| container_title | Journal of medical virology |
| container_volume | 84 |
| creator | Kling, Courtney L. Wright, Alexandra T. Katz, Sophie E. McClure, Gloria B. Gardner, J. Suzette Williams, Jason T. Meinerz, Natalie M. Garcea, Robert L. Vanchiere, John A. |
| description | The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.23319 |
| format | article |
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Suzette ; Williams, Jason T. ; Meinerz, Natalie M. ; Garcea, Robert L. ; Vanchiere, John A.</creator><creatorcontrib>Kling, Courtney L. ; Wright, Alexandra T. ; Katz, Sophie E. ; McClure, Gloria B. ; Gardner, J. Suzette ; Williams, Jason T. ; Meinerz, Natalie M. ; Garcea, Robert L. ; Vanchiere, John A.</creatorcontrib><description>The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.23319</identifier><identifier>PMID: 22825825</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Antibodies, Viral - blood ; Asymptomatic Infections ; Biological and medical sciences ; BK virus ; BK Virus - immunology ; BK Virus - physiology ; Epidemiology ; Estrogens ; Female ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; Infectious diseases ; JC virus ; JC Virus - immunology ; JC Virus - physiology ; Medical sciences ; Menstrual Cycle ; Menstruation ; Microbiology ; Miscellaneous ; polyomavirus ; Polyomavirus Infections - blood ; Polyomavirus Infections - urine ; Polyomavirus Infections - virology ; Tumor Virus Infections - blood ; Tumor Virus Infections - urine ; Tumor Virus Infections - virology ; Viral diseases ; Viral Load - physiology ; Virology ; Virus Replication ; Virus Shedding ; Young Adult</subject><ispartof>Journal of medical virology, 2012-09, Vol.84 (9), p.1459-1463</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2012 Wiley Periodicals, Inc. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6109-35af99bf6b87610a70276e52fff481d916d00154fa1fb34e6f279149dc0b2b323</citedby><cites>FETCH-LOGICAL-c6109-35af99bf6b87610a70276e52fff481d916d00154fa1fb34e6f279149dc0b2b323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26175824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22825825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kling, Courtney L.</creatorcontrib><creatorcontrib>Wright, Alexandra T.</creatorcontrib><creatorcontrib>Katz, Sophie E.</creatorcontrib><creatorcontrib>McClure, Gloria B.</creatorcontrib><creatorcontrib>Gardner, J. Suzette</creatorcontrib><creatorcontrib>Williams, Jason T.</creatorcontrib><creatorcontrib>Meinerz, Natalie M.</creatorcontrib><creatorcontrib>Garcea, Robert L.</creatorcontrib><creatorcontrib>Vanchiere, John A.</creatorcontrib><title>Dynamics of urinary polyomavirus shedding in healthy adult women</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Asymptomatic Infections</subject><subject>Biological and medical sciences</subject><subject>BK virus</subject><subject>BK Virus - immunology</subject><subject>BK Virus - physiology</subject><subject>Epidemiology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>JC virus</subject><subject>JC Virus - immunology</subject><subject>JC Virus - physiology</subject><subject>Medical sciences</subject><subject>Menstrual Cycle</subject><subject>Menstruation</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>polyomavirus</subject><subject>Polyomavirus Infections - blood</subject><subject>Polyomavirus Infections - urine</subject><subject>Polyomavirus Infections - virology</subject><subject>Tumor Virus Infections - blood</subject><subject>Tumor Virus Infections - urine</subject><subject>Tumor Virus Infections - virology</subject><subject>Viral diseases</subject><subject>Viral Load - physiology</subject><subject>Virology</subject><subject>Virus Replication</subject><subject>Virus Shedding</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkVtrFDEcxYModlt98AvIgAj1YdrcJpm8FKVqq20VxEvxJWRmkm7WTLImM1vn2xvd7XoBEQKB5Pc_5yQHgAcIHiAI8eGiXx1gQpC4BWYIClYKyNFtMIOIspIxVO2A3ZQWEMJaYHwX7GBc4yqvGXj6fPKqt20qginGaL2KU7EMbgq9Wtk4piLNdddZf1VYX8y1csN8KlQ3uqG4Dr3298Ado1zS9zf7Hvjw8sX749Py_O3Jq-Nn52XLcqSSVMoI0RjW1DwfKA4xZ7rCxhhao04g1kGIKmoUMg2hmhnMBaKia2GDG4LJHjha6y7Hptddq_0QlZPLaPscWQZl5Z833s7lVVhJChEkCGWB_Y1ADF9HnQbZ29Rq55TXYUwSUUoIrzET_0dz-JpUooIZffQXughj9PknsiCpEc8Uz9STNdXGkFLUZpsbQfmjQpkrlD8rzOzD3x-6JW86y8DjDaBSq5yJyrc2_eJYNq0xzdzhmru2Tk__dpSvLz7eWJfrCZsG_W07oeIXyTjhlfz05kSesYt3p5efz-Ql-Q4xZ8EP</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Kling, Courtney L.</creator><creator>Wright, Alexandra T.</creator><creator>Katz, Sophie E.</creator><creator>McClure, Gloria B.</creator><creator>Gardner, J. 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Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>JC virus</topic><topic>JC Virus - immunology</topic><topic>JC Virus - physiology</topic><topic>Medical sciences</topic><topic>Menstrual Cycle</topic><topic>Menstruation</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>polyomavirus</topic><topic>Polyomavirus Infections - blood</topic><topic>Polyomavirus Infections - urine</topic><topic>Polyomavirus Infections - virology</topic><topic>Tumor Virus Infections - blood</topic><topic>Tumor Virus Infections - urine</topic><topic>Tumor Virus Infections - virology</topic><topic>Viral diseases</topic><topic>Viral Load - physiology</topic><topic>Virology</topic><topic>Virus Replication</topic><topic>Virus Shedding</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kling, Courtney L.</creatorcontrib><creatorcontrib>Wright, Alexandra T.</creatorcontrib><creatorcontrib>Katz, Sophie E.</creatorcontrib><creatorcontrib>McClure, Gloria B.</creatorcontrib><creatorcontrib>Gardner, J. 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Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22825825</pmid><doi>10.1002/jmv.23319</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Antibodies, Viral - blood Asymptomatic Infections Biological and medical sciences BK virus BK Virus - immunology BK Virus - physiology Epidemiology Estrogens Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans Infectious diseases JC virus JC Virus - immunology JC Virus - physiology Medical sciences Menstrual Cycle Menstruation Microbiology Miscellaneous polyomavirus Polyomavirus Infections - blood Polyomavirus Infections - urine Polyomavirus Infections - virology Tumor Virus Infections - blood Tumor Virus Infections - urine Tumor Virus Infections - virology Viral diseases Viral Load - physiology Virology Virus Replication Virus Shedding Young Adult |
| title | Dynamics of urinary polyomavirus shedding in healthy adult women |
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