Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era

Metastatic lymph nodes (LN) are an adverse prognostic factor in head and neck squamous cell carcinoma (SCC). In this study, we tested the hypothesis that nodal metastases have reduced impact on survival in tonsil cancer in the HPV-predominant era. Incidence and mortality data of tonsil and oral cavi...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2014-09, Vol.271 (9), p.2523-2529
Main Authors: Vila, Peter M., Stucken, Chaz L., Morris, Luc G. T., Posner, Marshall R., Genden, Eric M., Boffetta, Paolo, Sikora, Andrew G.
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - virology
Female
Head and Neck
Head and Neck Surgery
Humans
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neck
Neurosurgery
Otorhinolaryngology
Papillomaviridae
Papillomavirus Infections - mortality
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Prognosis
Retrospective Studies
SEER Program
Survival Rate - trends
Tonsillar Neoplasms - mortality
Tonsillar Neoplasms - pathology
Tonsillar Neoplasms - virology
United States - epidemiology
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Summary:Metastatic lymph nodes (LN) are an adverse prognostic factor in head and neck squamous cell carcinoma (SCC). In this study, we tested the hypothesis that nodal metastases have reduced impact on survival in tonsil cancer in the HPV-predominant era. Incidence and mortality data of tonsil and oral cavity SCC between 1988 and 2007 were obtained from the SEER database. Based on published literature, we considered cases of tonsil cancer from 1988 to 1997 as the pre-HPV cohort ( N  = 752), and 1998–2007 as the HPV-predominant cohort ( N  = 2,755). Comparing the two cohorts, Kaplan–Meier 5-year overall survival (OS) for tonsil SCC improved from 54.0 to 74.3 % ( p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-013-2796-2