No association of dietary fiber intake with inflammation or arterial stiffness in youth with type 1 diabetes

• Published in: Journal of diabetes and its complications 2014-05, Vol.28 (3), p.305-310
• Main Authors: Jaacks, Lindsay M, Crandell, Jamie, Liese, Angela D, Lamichhane, Archana P, Bell, Ronny A, Dabelea, Dana, D’Agostino, Ralph B, Dolan, Lawrence M, Marcovina, Santica, Reynolds, Kristi, Shah, Amy S, Urbina, Elaine M, Wadwa, R. Paul, Mayer-Davis, Elizabeth J
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Age Factors; Arterial stiffness; Biomarkers - metabolism; Cardiovascular disease; Child; Cohort Studies; Diabetes; Diabetes Mellitus, Type 1 - physiopathology; Dietary fiber; Dietary Fiber - pharmacology; Endocrinology & Metabolism; Female; Fibrinogen - metabolism; Humans; Inflammation; Inflammation - physiopathology; Linear Models; Male; Mortality; Nutrition research; Pulse Wave Analysis; Retrospective Studies; Studies; Teenagers; Type 1 diabetes; United States; Vascular Stiffness - drug effects; Vascular Stiffness - physiology; Veins & arteries; Youth
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2014.01.005

Abstract Aim To examine the association of dietary fiber intake with inflammation and arterial stiffness among youth with type 1 diabetes (T1D) in the US. Methods Data are from youth ≥ 10 years old with clinically diagnosed T1D for ≥ 3 months and ≥ 1 positive diabetes autoantibody in the SEARCH for Diabetes in Youth Study. Fiber intake was assessed by food frequency questionnaire with measurement error (ME) accounted for by structural sub-models derived using additional 24-h dietary recall data in a calibration sample and the respective exposure-disease model covariates. Markers of inflammation, measured at baseline, included IL-6 ( n = 1405), CRP ( n = 1387), and fibrinogen ( n = 1340); markers of arterial stiffness, measured approximately 19 months post-baseline, were available in a subset of participants and included augmentation index ( n = 180), pulse wave velocity ( n = 184), and brachial distensibility ( n = 177). Results Mean (SD) T1D duration was 47.9 (43.2) months; 12.5% of participants were obese. Mean (SD) ME-adjusted fiber intake was 15 (2.8) g/day. In multivariable analyses, fiber intake was not associated with inflammation or arterial stiffness. Conclusion Among youth with T1D, fiber intake does not meet recommendations and is not associated with measures of systemic inflammation or vascular stiffness. Further research is needed to evaluate whether fiber is associated with these outcomes in older individuals with T1D or among individuals with higher intakes than those observed in the present study.