Ribotype 027 Clostridium difficile infections with measurable stool toxin have increased lactoferrin and are associated with a higher mortality

We evaluated clinical and diagnostic indicators of severe C. difficile infection (CDI) and their association with poor clinical outcome. A total of 210 patients positive according to PCR (toxin B: tcd B) were included, with patients having a median age of 62 years and a Charlson co-morbidity index (...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2014-06, Vol.33 (6), p.1045-1051
Main Authors: Boone, J. H., Archbald-Pannone, L. R., Wickham, K. N., Carman, R. J., Guerrant, R. L., Franck, C. T., Lyerly, D. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Toxins - analysis
Biological and medical sciences
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood
Clinical outcomes
Clostridium difficile
Clostridium difficile - classification
Clostridium difficile - genetics
Clostridium difficile - isolation & purification
Clostridium Infections - microbiology
Clostridium Infections - mortality
Clostridium Infections - pathology
Cohort Studies
Creatinine
Feces
Feces - chemistry
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hospitalization
Human bacterial diseases
Humans
Infections
Infectious diseases
Intensive care
Internal Medicine
Laboratories
Lactoferrin - analysis
Leukocytes
Male
Medical Microbiology
Medical records
Medical sciences
Middle Aged
Mortality
Other diseases. Semiology
Patients
R&D
Research & development
Ribotyping
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Toxins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated clinical and diagnostic indicators of severe C. difficile infection (CDI) and their association with poor clinical outcome. A total of 210 patients positive according to PCR (toxin B: tcd B) were included, with patients having a median age of 62 years and a Charlson co-morbidity index (CI) score of 5. Ninety-one percent ( n  = 191) were positive by toxigenic culture and 61 % ( n  = 129) had stool toxin. Toxin-positive patients had significantly higher fecal lactoferrin (mean 316 μg/g versus 106 μg/g stool; p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-013-2043-1