Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography

Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiothera...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radiation research 2014-05, Vol.55 (3), p.502-508
Main Authors: INOUE, Toshihiko, MASAI, Norihisa, OH, Ryoong-Jin, SHIOMI, Hiroya, HASHIDA, Noriyasu
Format: Article
Language:English
Subjects:
Assessments
Breast
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Cancer
Cancer metastasis
Choroid Neoplasms - pathology
Choroid Neoplasms - radiotherapy
Choroid Neoplasms - secondary
Female
Humans
Lesions
Melanoma - pathology
Melanoma - radiotherapy
Melanoma - secondary
Middle Aged
Oncology
Optical Coherence Tomography
Organs
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Image-Guided - methods
Tomography
Tomography, Optical Coherence - methods
Treatment Outcome
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiotherapy (IMRT) for a patient with choroidal metastasis from breast cancer with more accuracy than had been previously possible. We made replanning adaptive radiotherapy (ART) three times based on the rapid tumor shrinkage detected by weekly assessments with SS-OCT. Accordingly, the planning target volume (PTV) decreased from 1.6 cm3 to 0.61 cm3 (38%), with 0.95 cm3 (59%) and 0.75 cm3 (46%) as intermediate values during the treatment course. The D0.1 cm3 of the right optic nerve was also reduced from 1.70 Gy/fraction to 0.69 Gy/faction, with 1.41 Gy/fraction and 1.29 Gy/fraction as intermediate values. Adaptive replanning IMRT made it possible to perform locally curative treatment of the metastatic choroidal lesion with a higher dose for the PTV, and a lower dose for organs at risk (OARs).
ISSN:0449-3060
1349-9157
DOI:10.1093/jrr/rru023