Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chr...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2014-01, Vol.7 (4), p.1800-1804
Main Authors: Holdener, Stephanie L, Harrington, Lacey, Nguyen, Johnny, Horna, Pedro, Sagatys, Elizabeth, Shah, Bijal, Zhang, Ling
Format: Article
Language:English
Subjects:
Case Report
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 4 - genetics
Cyclin D1 - genetics
DNA-Binding Proteins - genetics
Drug Therapy
Drug-Related Side Effects and Adverse Reactions - complications
Gene Rearrangement
Histone-Lysine N-Methyltransferase
Humans
Immunoglobulin Heavy Chains - genetics
Lymphoma, Mantle-Cell - drug therapy
Male
Middle Aged
Myeloid-Lymphoid Leukemia Protein - genetics
Nuclear Proteins - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Transcriptional Elongation Factors
Translocation, Genetic - genetics
Treatment Outcome
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Summary:Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).
ISSN:1936-2625