Arterial stiffness and renal impairment in non‐proteinuric type 2 diabetic patients

Aims/Introduction:  Although increases in urinary protein excretion generally precede a decline in the glomerular filtration rate, non‐proteinuric renal impairment is common in patients with diabetes. In the present study, we examined the relationship between indices of arterial stiffness and renal...

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Published in:Journal of diabetes investigation 2012-02, Vol.3 (1), p.86-91
Main Authors: Nakao, Keiko, Uzu, Takashi, Araki, Shin‐ichi, Kume, Shinji, Deji, Naoko, Chin‐Kanasaki, Masami, Araki, Hisazumi, Isshiki, Keiji, Sugimoto, Toshiro, Kawai, Hiromichi, Nishio, Yoshihiko, Kashiwagi, Atsunori, Maegawa, Hiroshi
Format: Article
Language:English
Subjects:
Albuminuria
Ankle
Blood pressure
Chronic kidney disease
Diabetes
Multivariate analysis
Original
Vascular compliance
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Summary:Aims/Introduction:  Although increases in urinary protein excretion generally precede a decline in the glomerular filtration rate, non‐proteinuric renal impairment is common in patients with diabetes. In the present study, we examined the relationship between indices of arterial stiffness and renal function in type 2 diabetic patients without proteinuria. Methods:  Blood sampling, 24‐h urine collection, brachial–ankle pulse wave velocity, and 24‐h ambulatory blood pressure monitoring were performed in type 2 diabetic patients without overt proteinuria. The ambulatory arterial stiffness index was calculated as (1 – the regression slope of diastolic/systolic ambulatory blood pressure). Estimated glomerular filtration rate (eGFR)was calculated using the simplified prediction equation proposed by the Japanese Society of Nephrology. Results:  Of 213 non‐proteinuric patients with type 2 diabetes, 60 (28.2%) had a reduced eGFR (
ISSN:2040-1116
2040-1124
DOI:10.1111/j.2040-1124.2011.00146.x