Isolation of two tissue‐specific Drosophila paired box genes, Pox meso and Pox neuro

Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain genes, paired and gooseberry, which contain both a paired and a homeo‐domain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that th...

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Bibliographic Details
Published in:The EMBO journal 1989-11, Vol.8 (11), p.3447-3457
Main Authors: Bopp, D., Jamet, E., Baumgartner, S., Burri, M., Noll, M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Diptera
Drosophila
Drosophila melanogaster - genetics
Drosophilidae
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes
Genes, Homeobox
Genes. Genome
Immunohistochemistry
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nuclear Proteins - genetics
Organ Specificity - genetics
Phenotype
Sequence Homology, Nucleic Acid
Transcription Factors - genetics
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Summary:Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain genes, paired and gooseberry, which contain both a paired and a homeo‐domain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that the new genes encode tissue‐specific transcriptional factors and belong to the same regulatory cascade as the other paired domain genes includes (i) tissue‐specific expression of Pox meso in the somatic mesoderm and of Pox neuro in the central and peripheral nervous system, (ii) nuclear localization of their proteins, (iii) dependence on prd activity and (iv) presence of the paired domain in genes of known regulatory activity. While no mutant phenotypes of Pox meso and Pox neuro have yet been discovered, a murine gene with a paired domain closely homologous to that of Pox meso has recently been identified with the undulated mutant. Both Pox meso and undulated are expressed in tissues derived from the somatic mesoderm. The five known Drosophila paired domains fall into three classes: (i) the prd,gsb‐class, (ii) the Pox meso, undulated‐class and (iii) the Pox neuro‐class which probably includes the paired domain of the murine gene Pax 2.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1989.tb08509.x