Histone variants: dynamic punctuation in transcription

Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas...

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Bibliographic Details
Published in:Genes & development 2014-04, Vol.28 (7), p.672-682
Main Authors: Weber, Christopher M, Henikoff, Steven
Format: Article
Language:English
Subjects:
Animals
Chromatin - metabolism
Gene Expression Regulation
Histones - genetics
Histones - metabolism
Nucleosomes - metabolism
Review
Transcription, Genetic - genetics
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Summary:Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.238873.114