Emerging filoviral disease in Uganda: proposed explanations and research directions

Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservoir of the viruses, and fluctuations in viral load...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2014-05, Vol.90 (5), p.790-793
Main Authors: Polonsky, Jonathan A, Wamala, Joseph F, de Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Porten, Klaudia, Shoemaker, Trevor
Format: Article
Language:English
Subjects:
Animals
Chiroptera - virology
Disease Outbreaks
Ebola virus
Ebolavirus - isolation & purification
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - transmission
Hemorrhagic Fever, Ebola - virology
Host-Pathogen Interactions
Humans
Marburg virus
Marburg Virus Disease - epidemiology
Marburg Virus Disease - transmission
Marburg Virus Disease - virology
Marburgvirus - isolation & purification
Piece
Prevalence
Uganda - epidemiology
Viral Load
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Summary:Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservoir of the viruses, and fluctuations in viral load and prevalence within this reservoir. The roles of these proposed explanations must be investigated in order to guide appropriate responses to the changing epidemiological profile. Other African settings in which multiple filoviral outbreaks have occurred could also benefit from such information.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.13-0374