Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification

Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothel...

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Published in:Cardiovascular diabetology 2013-10, Vol.12 (1), p.149-149, Article 149
Main Authors: van Eupen, Marcelle G A, Schram, Miranda T, Colhoun, Helen M, Scheijen, Jean L J M, Stehouwer, Coen D A, Schalkwijk, Casper G
Format: Article
Language:English
Subjects:
Adult
Advanced glycosylation end products
Arginine - analogs & derivatives
Arginine - blood
Biomarkers - blood
C-Reactive Protein - metabolism
Cardiovascular disease
Case-Control Studies
Chromatography, High Pressure Liquid
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Vessels - diagnostic imaging
Diabetes
Diabetes Mellitus, Type 1 - blood
Female
Glycation End Products, Advanced - blood
Humans
Lysine - analogs & derivatives
Lysine - blood
Male
Middle Aged
Original Investigation
Plasma
Pyrimidines - blood
Studies
Tomography, X-Ray Computed
Vascular Calcification - blood
Vascular Calcification - diagnostic imaging
Vascular Cell Adhesion Molecule-1 - blood
Veins & arteries
von Willebrand Factor - metabolism
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cited_by cdi_FETCH-LOGICAL-c524t-23c4c6be14a8ebe7ad62ce7501c036fd8b3ffe191b5f6238296f4abc153b474a3
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container_title Cardiovascular diabetology
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creator van Eupen, Marcelle G A
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Colhoun, Helen M
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Schalkwijk, Casper G
description Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). We studied 165 individuals with and 169 without T1DM. CAC was quantified in a CAC score based on CT-scanning. Plasma levels of protein-bound pentosidine, Nϵ-(carboxymethyl)lysine (CML) and Nϵ-(carboxyethyl)lysine (CEL) were measured with HPLC/UPLC with fluorescence detection or tandem-mass spectrometry. Tetrahydropyrimidine (THP) was measured with ELISA, as were HsCRP, and sVCAM-1 and vWF, as markers for LGI and ED, respectively. Associations were analyzed with ANCOVA and adjusted for age, sex, BMI, waist-to-hip ratio, smoking, blood pressure, lipid profile, eGFR and T1DM. Individuals with T1DM had higher plasma levels of pentosidine, CML and THP compared with controls; means (95% CI) were 0.69 (0.65-0.73) vs. 0.51 (0.48-0.54) nmol/mmol LYS, p 
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We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). We studied 165 individuals with and 169 without T1DM. CAC was quantified in a CAC score based on CT-scanning. Plasma levels of protein-bound pentosidine, Nϵ-(carboxymethyl)lysine (CML) and Nϵ-(carboxyethyl)lysine (CEL) were measured with HPLC/UPLC with fluorescence detection or tandem-mass spectrometry. Tetrahydropyrimidine (THP) was measured with ELISA, as were HsCRP, and sVCAM-1 and vWF, as markers for LGI and ED, respectively. Associations were analyzed with ANCOVA and adjusted for age, sex, BMI, waist-to-hip ratio, smoking, blood pressure, lipid profile, eGFR and T1DM. Individuals with T1DM had higher plasma levels of pentosidine, CML and THP compared with controls; means (95% CI) were 0.69 (0.65-0.73) vs. 0.51 (0.48-0.54) nmol/mmol LYS, p &lt; 0.001; 105 (102-107) vs. 93 (90-95) nmol/mmol LYS, p &lt; 0.001; and 126 (118-134) vs. 113 (106-120) U/mL, p = 0.03, respectively. Levels of pentosidine were higher in individuals with T1DM with a moderate to high compared with a low CAC score, means (95% CI) were 0.81 (0.70-0.93) vs. 0.67 (0.63-0.71) nmol/mmol LYS, p = 0.03, respectively. This difference was not attenuated by adjustment for LGI or ED. We found a positive association between pentosidine and CAC in T1DM. These results may indicate that AGEs are possibly involved in the development of CAC in individuals with T1DM.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/1475-2840-12-149</identifier><identifier>PMID: 24134530</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adult ; Advanced glycosylation end products ; Arginine - analogs &amp; derivatives ; Arginine - blood ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Case-Control Studies ; Chromatography, High Pressure Liquid ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Vessels - diagnostic imaging ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Female ; Glycation End Products, Advanced - blood ; Humans ; Lysine - analogs &amp; derivatives ; Lysine - blood ; Male ; Middle Aged ; Original Investigation ; Plasma ; Pyrimidines - blood ; Studies ; Tomography, X-Ray Computed ; Vascular Calcification - blood ; Vascular Calcification - diagnostic imaging ; Vascular Cell Adhesion Molecule-1 - blood ; Veins &amp; arteries ; von Willebrand Factor - metabolism</subject><ispartof>Cardiovascular diabetology, 2013-10, Vol.12 (1), p.149-149, Article 149</ispartof><rights>2013 van Eupen et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 van Eupen et al.; licensee BioMed Central Ltd. 2013 van Eupen et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-23c4c6be14a8ebe7ad62ce7501c036fd8b3ffe191b5f6238296f4abc153b474a3</citedby><cites>FETCH-LOGICAL-c524t-23c4c6be14a8ebe7ad62ce7501c036fd8b3ffe191b5f6238296f4abc153b474a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1458391825?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24134530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Eupen, Marcelle G A</creatorcontrib><creatorcontrib>Schram, Miranda T</creatorcontrib><creatorcontrib>Colhoun, Helen M</creatorcontrib><creatorcontrib>Scheijen, Jean L J M</creatorcontrib><creatorcontrib>Stehouwer, Coen D A</creatorcontrib><creatorcontrib>Schalkwijk, Casper G</creatorcontrib><title>Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification</title><title>Cardiovascular diabetology</title><addtitle>Cardiovasc Diabetol</addtitle><description>Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). 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We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). We studied 165 individuals with and 169 without T1DM. CAC was quantified in a CAC score based on CT-scanning. Plasma levels of protein-bound pentosidine, Nϵ-(carboxymethyl)lysine (CML) and Nϵ-(carboxyethyl)lysine (CEL) were measured with HPLC/UPLC with fluorescence detection or tandem-mass spectrometry. Tetrahydropyrimidine (THP) was measured with ELISA, as were HsCRP, and sVCAM-1 and vWF, as markers for LGI and ED, respectively. Associations were analyzed with ANCOVA and adjusted for age, sex, BMI, waist-to-hip ratio, smoking, blood pressure, lipid profile, eGFR and T1DM. 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subjects Adult
Advanced glycosylation end products
Arginine - analogs & derivatives
Arginine - blood
Biomarkers - blood
C-Reactive Protein - metabolism
Cardiovascular disease
Case-Control Studies
Chromatography, High Pressure Liquid
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Vessels - diagnostic imaging
Diabetes
Diabetes Mellitus, Type 1 - blood
Female
Glycation End Products, Advanced - blood
Humans
Lysine - analogs & derivatives
Lysine - blood
Male
Middle Aged
Original Investigation
Plasma
Pyrimidines - blood
Studies
Tomography, X-Ray Computed
Vascular Calcification - blood
Vascular Calcification - diagnostic imaging
Vascular Cell Adhesion Molecule-1 - blood
Veins & arteries
von Willebrand Factor - metabolism
title Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification
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