High Drinking in the Dark Mice: A genetic model of drinking to intoxication

Abstract Drinking to intoxication is a critical component of risky drinking behaviors in humans, such as binge drinking. Previous rodent models of alcohol consumption largely failed to demonstrate that animals were patterning drinking in such a way as to experience intoxication. Therefore, few roden...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2014-05, Vol.48 (3), p.217-223
Main Authors: Barkley-Levenson, Amanda M, Crabbe, John C
Format: Article
Language:English
Subjects:
Alcohol Drinking - genetics
Alcohol use
Alcoholic Intoxication - genetics
Alcoholism
Animals
Behavior
Binge
Circadian Rhythm
Darkness
Disease Models, Animal
Drinking in the dark
Ethanol - blood
Ethanol consumption
Genetics
Mice
Psychiatry
Rodents
Selective breeding
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Summary:Abstract Drinking to intoxication is a critical component of risky drinking behaviors in humans, such as binge drinking. Previous rodent models of alcohol consumption largely failed to demonstrate that animals were patterning drinking in such a way as to experience intoxication. Therefore, few rodent models of binge-like drinking and no specifically genetic models were available to study possible predisposing genes. The High Drinking in the Dark (HDID) selective breeding project was started to help fill this void, with HDID mice selected for reaching high blood alcohol levels in a limited access procedure. HDID mice now represent a genetic model of drinking to intoxication and can be used to help answer questions regarding predisposition toward this trait as well as potential correlated responses. They should also prove useful for the eventual development of better therapeutic strategies.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2013.10.007