Increase in hippocampal water diffusion and volume during experimental pneumococcal meningitis is aggravated by bacteremia

The hippocampus undergoes apoptosis in experimental pneumococcal meningitis leading to neurofunctional deficits in learning and memory function. The aim of the present study was 1) to investigate hippocampal apparent diffusion coefficient (ADC) and volume with MRI during the course of experimental p...

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Bibliographic Details
Published in:BMC infectious diseases 2014-05, Vol.14 (1), p.240-240, Article 240
Main Authors: Holler, Jon G, Brandt, Christian T, Leib, Stephen L, Rowland, Ian J, Østergaard, Christian
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bacteremia - metabolism
Bacteremia - microbiology
Bacteremia - pathology
Brain
Cerebral Cortex - metabolism
Cerebral Ventricles - pathology
Diffusion
Disease Models, Animal
Hippocampus - metabolism
Hippocampus - pathology
Magnetic Resonance Imaging
Male
Meningitis
Meningitis, Pneumococcal - metabolism
Meningitis, Pneumococcal - pathology
Rats
Rats, Wistar
Rodents
Streptococcus pneumoniae
Studies
Water - metabolism
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Summary:The hippocampus undergoes apoptosis in experimental pneumococcal meningitis leading to neurofunctional deficits in learning and memory function. The aim of the present study was 1) to investigate hippocampal apparent diffusion coefficient (ADC) and volume with MRI during the course of experimental pneumococcal meningitis, 2) to explore the influence of accompanying bacteremia on hippocampal water distribution and volume, 3) and to correlate these findings to the extent of apoptosis in the hippocampus. Experimental meningitis in rats was induced by intracisternal injection of live pneumococci. The study comprised of four experimental groups. I. Uninfected controls (n = 8); II. Meningitis (n = 11); III. Meningitis with early onset bacteremia by additional i.v. injection of live pneumococci (n = 10); IV. Meningitis with attenuated bacteremia by treatment with serotype-specific anti-pneumococcal antibodies (n = 14). T2 and diffusion weighted MR images were used to analyze changes in hippocampus volume and water diffusion (ADC). The results were correlated to ADC of the cortex, to ventricular volume, and to the extent of hippocampal apoptosis. Both ADC and the volume of hippocampus were significantly increased in meningitis rats compared to uninfected controls (Kruskal-Wallis test, p = 0.0001, Dunns Post Test, p 
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-14-240