Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale

With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy ind...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Šáchová, Jana, Čapková, Markéta, Strnad, Hynek, Kolář, Michal, Hroudová, Miluše, Chovanec, Martin, Čada, Zdeněk, Šteffl, Martin, Valach, Jaroslav, Kastner, Jan, Vlček, Čestmír, Smetana, Karel, Plzak, Jan
Format: Article
Language:English
Subjects:
Adult
Aged
Apoptosis
Apoptosis - genetics
Bioinformatics
Biomarkers
Biopsy
Cancer
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Demography
DNA microarrays
Epigenetics
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human - genetics
Head and neck cancer
Head and Neck Neoplasms - blood
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - pathology
Humans
Male
Medical prognosis
Medicine
Messenger RNA
Microarray Analysis
Middle Aged
Otolaryngology
Patients
Principal Component Analysis
Principal components analysis
RNA, Messenger - blood
RNA, Messenger - genetics
Signal Transduction - genetics
Squamous Cell Carcinoma of Head and Neck
Studies
Surgery
Tumor Suppressor Protein p53 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compared gene expression patterns of 36 samples. Twenty-four participants including 16 HNSCC patients (from 12 patients we obtained blood samples 1 year posttreatment) and 8 control subjects were recruited. The Illumina HumanWG-6 v3 Expression BeadChip was used to profile and identify the differences in serum mRNA transcriptomes. We found 159 genes to be significantly changed (Storey’s P value
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/408683