Recent Updates in the Treatment of Neurodegenerative Disorders Using Natural Compounds

Neurodegenerative diseases are characterized by protein aggregates and inflammation as well as oxidative stress in the central nervous system (CNS). Multiple biological processes are linked to neurodegenerative diseases such as depletion or insufficient synthesis of neurotransmitters, oxidative stre...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Gan, Siew Hua, Sheikh, Ishfaq Ahmed, Kamal, Mohammad Amjad, Qazi, Mahmood Husain, Asif, Muhammad, Pushparaj, Peter Natesan, Manan, Abdul, Qureshi, Muhammad Saeed, Malik, Arif, Rasool, Mahmood, Qazi, Aamer Mahmood
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Apoptosis
Autism
Blood-brain barrier
Brain
Brain research
Central nervous system
Chemical compounds
Enzymes
Inflammation
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neurosciences
Neurotransmitters
Oxidative stress
Physiology
Proteins
Review
Side effects
Tumor necrosis factor-TNF
Ubiquitination
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Summary:Neurodegenerative diseases are characterized by protein aggregates and inflammation as well as oxidative stress in the central nervous system (CNS). Multiple biological processes are linked to neurodegenerative diseases such as depletion or insufficient synthesis of neurotransmitters, oxidative stress, abnormal ubiquitination. Furthermore, damaging of blood brain barrier (BBB) in the CNS also leads to various CNS-related diseases. Even though synthetic drugs are used for the management of Alzheimer’s disease, Parkinson’s disease, autism, and many other chronic illnesses, they are not without side effects. The attentions of researchers have been inclined towards the phytochemicals, many of which have minimal side effects. Phytochemicals are promising therapeutic agents because many phytochemicals have anti-inflammatory, antioxidative as well as anticholinesterase activities. Various drugs of either synthetic or natural origin applied in the treatment of brain disorders need to cross the BBB before they can be used. This paper covers various researches related to phytochemicals used in the management of neurodegenerative disorders.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/979730