Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides

Novel type 1 phototherapeutic agents based on compounds containing S–N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious...

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Published in:ACS medicinal chemistry letters 2011-11, Vol.2 (11), p.828-833
Main Authors: Karwa, Amolkumar S, Poreddy, Amruta R, Asmelash, Bethel, Lin, Tien-Sung, Dorshow, Richard B, Rajagopalan, Raghavan
Format: Article
Language:English
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Letter
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Summary:Novel type 1 phototherapeutic agents based on compounds containing S–N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.
ISSN:1948-5875
1948-5875
DOI:10.1021/ml2001483