Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate

Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal me...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2013-05, Vol.165 (1), p.70-78
Main Authors: Wone, Bernard W.M., Donovan, Edward R., Cushman, John C., Hayes, Jack P.
Format: Article
Language:English
Subjects:
Aerobic capacity
Animals
Artificial selection
Basal metabolic rate
Basal Metabolism
Body Weight
Energy Metabolism
Evolutionary physiology
Fatty acid
fatty acids
Fatty Acids - metabolism
liver
Liver - metabolism
Membranes - metabolism
Metabolic rate
Metabolism
Mice
Muscle, Skeletal - metabolism
muscles
Network analysis
skeletal muscle
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Summary:Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpa.2013.02.010