Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type 1 superinfection

We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the...

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Bibliographic Details
Published in:Journal of virology 2014-05, Vol.88 (10), p.5894-5899
Main Authors: Blish, Catherine A, Dogan, Ozge C, Jaoko, Walter, McClelland, R Scott, Mandaliya, Kishorchandra, Odem-Davis, Katherine, Richardson, Barbra A, Overbaugh, Julie
Format: Article
Language:English
Subjects:
Case-Control Studies
Female
HIV Infections - immunology
HIV Infections - virology
HIV-1 - growth & development
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Pathogenesis and Immunity
Superinfection
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Summary:We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00187-14