Tissue-engineered kidney disease models

Renal disease represents a major health problem that often results in end-stage renal failure necessitating dialysis and eventually transplantation. Historically these diseases have been studied with patient observation and screening, animal models, and two-dimensional cell culture. In this review,...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2014-04, Vol.69-70, p.67-80
Main Authors: DesRochers, Teresa M., Palma, Erica, Kaplan, David L.
Format: Article
Language:English
Subjects:
3D tissues
Acute kidney injury
Animals
Cell Culture Techniques - methods
Cell Culture Techniques - trends
Cell Line, Transformed
Chronic kidney disease
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
Drug-induced nephrotoxicity
Glomerulus
Humans
Kidney Diseases - drug therapy
Kidney Diseases - pathology
Microfluidics
Models, Biological
Polycystic kidney disease
Renal
Renal Agents - therapeutic use
Renal cell carcinoma
Renal fibrosis
Tissue Engineering - methods
Tissue Engineering - trends
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Summary:Renal disease represents a major health problem that often results in end-stage renal failure necessitating dialysis and eventually transplantation. Historically these diseases have been studied with patient observation and screening, animal models, and two-dimensional cell culture. In this review, we focus on recent advances in tissue engineered kidney disease models that have the capacity to compensate for the limitations of traditional modalities. The cells and materials utilized to develop these models are discussed and tissue engineered models of polycystic kidney disease, drug-induced nephrotoxicity, and the glomerulus are examined in detail. The application of these models has the potential to direct future disease treatments and preclinical drug development. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2013.12.002